ketene

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Names

[ CAS No. ]:
463-51-4

[ Name ]:
ketene

[Synonym ]:
ketene
carbometene
oxoethylene
Ethen-1-one
ethylene-oxide
Keten
methylene ketone
methyleneoxaethylene
Carbomethene

Chemical & Physical Properties

[ Density]:
0.712 g/cm3

[ Boiling Point ]:
-56ºC

[ Melting Point ]:
-150ºC

[ Molecular Formula ]:
C2H2O

[ Molecular Weight ]:
42.03670

[ Exact Mass ]:
42.01060

[ PSA ]:
17.07000

[ LogP ]:
0.00400

[ Vapour Pressure ]:
12600mmHg at 25°C

[ Index of Refraction ]:
1.303

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OA7700000
CHEMICAL NAME :
Ketene
CAS REGISTRY NUMBER :
463-51-4
LAST UPDATED :
199712
DATA ITEMS CITED :
30
MOLECULAR FORMULA :
C2-H2-O
MOLECULAR WEIGHT :
42.04
WISWESSER LINE NOTATION :
OCU1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
23 ppm/30M
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,209,1949
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
200 ppm/10M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,209,1949
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
750 ppm/10M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,209,1949
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
53 ppm/2H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,209,1949
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
53 ppm/2H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,209,1949 *** REVIEWS *** ACGIH TLV-STEL 2.6 mg/m3 (1.5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.86 mg/m3 (0.5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 ppm (0.9 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,143,1971 OSHA PEL (Gen Indu):8H TWA 0.5 ppm (0.9 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 ppm (0.9 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 ppm (0.9 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 ppm (0.9 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.5 ppm (0.9 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 0.5 ppm (0.9 mg/m3);STEL 1.5 ppm (3 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.5 ppm (0.89 mg/m3);STEL 1.5 ppm (2.6 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.5 ppm (0.9 mg/m3) JAN 1993 OEL-FINLAND:STEL 0.5 ppm (0.9 mg/m3) JAN 1993 OEL-FRANCE:TWA 0.5 ppm (0.9 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.5 ppm (0.9 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.5 ppm (0.9 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 ppm (0.9 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.5 ppm (0.9 mg/m3);STEL 1 ppm (1.8 mg/m3) JAN 1993 OEL-TURKEY:TWA 0.5 ppm (0.9 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 ppm (0.9 mg/m3);STEL 1.5 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO KETENE-air:10H TWA 0.5 ppm;STEL 1.5 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 41840 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 66 (estimated)

Safety Information

[ RIDADR ]:
UN 1955

[ Hazard Class ]:
2.3

[ HS Code ]:
2914190090

Synthetic Route

Precursor & DownStream

Precursor

  • Bromoacetyl chloride
  • Phenoxatellurin
  • Ethanoic anhydride
  • acetic acid
  • dicarbonyl{1,1,1-tris((diphenylphosphino)methyl)ethane}ruthenium(0)
  • 3-Pentanone
  • 2-Butanone
  • Glycine
  • ethyl acetate
  • phenyl acetate

DownStream

  • Ethylfluorodimethylsilane
  • methyl [4-(N-hydroxyacetamido)phenyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid]uronate
  • 4-Acetamidophenyl-2,3,4-tri-O-acetyl-b-D-glucuronide methyl ester
  • (E)-3-Methyl-1,3-pentadiene
  • 2,3-DIMETHYL-1,3-BUTADIENE
  • 2H-Pyran-2-one,3,4-dihydro-6-methyl-
  • Acetyl bromide
  • Ethanethioic acid,1,1'-anhydrosulfide
  • Thioacetic acid
  • acetyl iodide

Customs

[ HS Code ]: 2914190090

[ Summary ]:
2914190090 other acyclic ketones without other oxygen function。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%


Related Compounds

  • Diketene
  • Diketene
  • Cyanoketene
  • ketene dimer
  • ketene dimer
  • methylketene
  • N-(piperidin-4-yl)benzo[d][1,3]dioxole-5-carboxamide hydrochloride
  • N,N,N',N'-Tetrapropyl-p-phenylenediamine
  • (2R)-2-amino-N-[1-(4-methoxyphenyl)ethyl]-3-methylbutanamide
  • N-(piperidin-3-ylmethyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide hydrochloride
  • N-[(1-ethylpyrrolidin-2-yl)methyl]-2-[(3,4,8-trimethyl-2-oxo-2H-chromen-7-yl)oxy]acetamide
  • 2-(7,8-dimethoxy-2-oxo-1,2-dihydro-3H-3-benzazepin-3-yl)-N-(2,4-dimethoxyphenyl)acetamide
  • 2-chloro-N-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-5-methylthiazole-4-carboxamide
  • N-(2-(3-(2-methoxyethoxyl)phenyl)pyrimidin-4-yl)-1H-indazol-5-amine
  • 2-[4-(acetylamino)-1H-indol-1-yl]-N-{3-[5-(methoxymethyl)-1H-1,2,4-triazol-3-yl]phenyl}acetamide
  • 2-{2-[(3-Hydroxyphenyl)amino]-1,3-thiazol-4-yl}acetic acid
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