4-Chlorobutyryl chloride

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Names

[ CAS No. ]:
4635-59-0

[ Name ]:
4-Chlorobutyryl chloride

[Synonym ]:
4-Chlorobutanoyl chloride
γ-Chlorobutyryl chloride
MFCD00000754
4-Chlorobutyryl chloride
4-Chlorobutyrylchloride
EINECS 225-059-1

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
174.3±13.0 °C at 760 mmHg

[ Melting Point ]:
-47 °C

[ Molecular Formula ]:
C4H6Cl2O

[ Molecular Weight ]:
140.996

[ Flash Point ]:
70.2±20.2 °C

[ Exact Mass ]:
139.979568

[ PSA ]:
17.07000

[ LogP ]:
1.44

[ Vapour Pressure ]:
1.2±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.442

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EM1406000
CHEMICAL NAME :
Butanoyl chloride, 4-chloro-
CAS REGISTRY NUMBER :
4635-59-0
LAST UPDATED :
199710
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C4-H6-Cl2-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
650 mg/m3/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570772

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H330

[ Precautionary Statements ]:
P260-P280-P284-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R22;R23;R35

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S28A

[ RIDADR ]:
UN 3390 6.1/PG 1

[ WGK Germany ]:
1

[ RTECS ]:
EM1406000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
29159080

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • gamma-Butyrolactone
  • 4-Chlorobutyric acid
  • Butyryl chloride
  • carbon monoxide
  • cyclopropane
  • benzene
  • Butyric Acid
  • phosgene
  • Benzotrichloride

DownStream

  • N-METHOXY-N-METHYLBUTYRAMIDE
  • (S)-N-(1-Amino-1-oxobutan-2-yl)-4-chlorobutanamide
  • 4-chloro-4'-methoxybutyrophenone
  • 1-(4-tert-butylphenyl)-4-chlorobutan-1-one
  • Ethyl 4-chlorobutanoate
  • Methyl 4-chlorobutanoate
  • 4-Chloro-p-fluorobutyrophenone
  • 3-Methylindanone
  • 4-(2-oxopyrrolidin-1-yl)benzoic acid
  • gamma-chloro-2-butyrothienone

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

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Biomacromolecules 6(2) , 858-63, (2005)

An efficient synthetic route was developed for the mild chloroacylation of chitosan with different chloroacyl chlorides. Full N-chloroacylation was obtained with this procedure without any O-acylation...

Radiosynthesis of (11)C-Levetiracetam: A Potential Marker for PET Imaging of SV2A Expression.

ACS Med. Chem. Lett. 5(10) , 1152-5, (2014)

The multistep preparation of (11)C-levetiracetam ((11)C-LEV) was carried out by a one-pot radiosynthesis with 8.3 ± 1.6% (n = 8) radiochemical yield in 50 ± 5.0 min. Briefly, the propionaldehyde was c...

Multikilogram-scale synthesis of a biphenyl carboxylic acid derivative using a Pd/C-mediated suzuki coupling approach. Ennis DS, et al.

Org. Process Res. Dev. 3(4) , 248-52, (1999)


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Related Compounds

  • 1-(3-chlorophenyl)-2-(ethylthio)-5-(p-tolyl)-1H-imidazole
  • 2-(2,1,3-benzothiadiazol-4-ylsulfonyl)-8-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
  • (3-bromophenyl)(6-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)methanone
  • [4-(2,1,3-Benzothiadiazol-4-ylsulfonyl)piperazin-1-yl](3-methoxyphenyl)methanone
  • 2-((1-(3-chlorophenyl)-5-(p-tolyl)-1H-imidazol-2-yl)thio)acetonitrile
  • N-[1-(2-methoxyethyl)-4,5-dimethyl-3-(phenylsulfonyl)-1H-pyrrol-2-yl]thiophene-2-carboxamide
  • 1-ethyl-N-(6-fluorobenzo[d]thiazol-2-yl)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide
  • N-{3-[(4-methoxyphenyl)sulfonyl]-4,5-dimethyl-1-(propan-2-yl)-1H-pyrrol-2-yl}furan-2-carboxamide
  • 2-(methylsulfanyl)-N-(4-phenylbutyl)pyridine-3-carboxamide
  • 3-(2,2-Dimethylpropyl)-4-ethyl-1H-pyrazol-5-amine
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