7-Azaindole-3-carboxaldehyde

Names

[ Name ]:
7-Azaindole-3-carboxaldehyde

[Synonym ]:
3-Formyl-1H-pyrrolo[2,3-b]pyridine
1H-pyrrolo[2,3-B]pyridine-3-carbaldehyde
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde
7-Azaindole-3-Carboxaldehyde
1H-Pyrrolo[2,3-b]pyridin-3-carbaldehyd

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
361.1±22.0 °C at 760 mmHg

[ Melting Point ]:
216-220ºC

[ Molecular Formula ]:
C₈H₆N₂O

[ Molecular Weight ]:
146.146

[ Flash Point ]:
176.0±28.8 °C

[ Exact Mass ]:
146.048019

[ PSA ]:
45.75000

[ LogP ]:
1.21

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.747

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H317-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

7-Azaindole
N,N-Dimethylformamide
acetic acid
Aminoform
Dichloromethyl methyl ether
3-Bromo-7-azaindole
1H-Pyrrolo[2,3-b]pyridin-3-amin
SodiuM bicarbonate
3-(DiMethylaMinoMethyl)-7-azaindole

DownStream

3-ethenyl-1H-pyrrolo[2,3-b]pyridine
4-bromo-2,5-dimethoxybenzene-1-sulfonyl chloride
1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 1-(phenylsulfonyl)-, ethyl ester
METHYL 1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE
1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID
1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethanone
3-(1-PIPERAZINYLMETHYL)-1H-PYRROLO[2,3-B]PYRIDINE
1H-Pyrrolo[2,3-B]Pyridin-3-Ylmethanol
tert-butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
TERT-BUTYL 3-(HYDROXYMETHYL)-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and antifungal activity of novel streptochlorin analogues.

Eur. J. Med. Chem. 92 , 776-83, (2015)

Streptochlorin, first isolated as a new antibiotic in 1988 from the lipophilic extracts of the mycelium of a Streptomyces sp, is an indole natural products with a variety of biological activities. Bas...

Synthesis and evaluation of fluorine-substituted 1H-pyrrolo[2,3-b]pyridine derivatives for dopamine D4 receptor imaging.

Bioorg. Med. Chem. 12 , 5505, (2004)

Seven fluorine-substituted 1H-pyrrolo[2,3-b]pyridine derivatives were synthesized based on a lead ligand, 3-[[4-(4-iodophenyl)piperazin-1-yl]-methyl]-1H-pyrrolo[2,3-b]pyridine (L-750,667) and evaluate...

J. Am. Chem. Soc. 77 , 457, (1995)

7-azaindole-3-carboxaldehyde oxime
5-iodo-7-azaindole-3-carboxaldehyde
5-Fluoro-7-azaindole-3-carboxaldehyde
6-Fluoro-7-azaindole-3-carboxaldehyde
4-(Trifluoromethyl)-7-azaindole-3-carboxaldehyde
5-(Trifluoromethyl)-7-azaindole-3-carboxaldehyde
3,3-Difluoro-1-(1,1,1,3,3,3-hexafluoropropan-2-yl)cyclobutan-1-amine
2-[1-(3-Methyloxetan-3-yl)cyclopropyl]ethan-1-amine
5-Ethyl-1,9-dioxa-4-azaspiro[5.5]undecane
(R)-3-[1-[[3-Chloro-7-fluoro-2-methyl-6-[2-(1-piperazinyl)-5-pyrimidinyl]-1,5-naphthyridin-4-yl]amino]ethyl]-4-fluorobenzonitrile
1-(3-Nitrophenyl)bicyclo[2.1.1]hexan-5-amine
3,3,9-Trimethyl-1-oxa-5,9-diazaspiro[5.6]dodecane
3-[(1H-imidazol-1-yl)methyl]oxolane-2-carbohydrazide
2-[(3S)-3-aminobutyl]-5-methoxyphenol
4-[(3-{[(tert-butoxy)carbonyl]amino}-2-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]propyl)({[(9H-fluoren-9-yl)methoxy]carbonyl})amino]butanoic acid
2-(1-methyl-1H-1,2,3-triazol-5-yl)prop-2-enoic acid

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