Oleandrin

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Names

[ CAS No. ]:
465-16-7

[ Name ]:
Oleandrin

[Synonym ]:
(3β,5β,16β)-16-(acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
Corrigen
OLEANDRIN
Neriolin
(3β,5β,16β)-16-Acetoxy-3-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
Cholesteryl-methyl-ether
Cholesterin-methylether
(3b,5b,16b)-16-(Acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
Folinerin
Cholesterin-monomethylether
EINECS 207-361-5

Chemical & Physical Properties

[ Density]:
1.26

[ Boiling Point ]:
693.7±55.0 °C at 760 mmHg

[ Melting Point ]:
250ºC

[ Molecular Formula ]:
C₃₂H₄₈O₉

[ Molecular Weight ]:
576.718

[ Flash Point ]:
217.2±25.0 °C

[ Exact Mass ]:
576.329834

[ PSA ]:
120.75000

[ LogP ]:
2.30

[ Vapour Pressure ]:
0.0±4.9 mmHg at 25°C

[ Index of Refraction ]:
1.567

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H330-H373

[ Precautionary Statements ]:
P260-P264-P284-P301 + P310-P310

[ Hazard Codes ]:
T

[ Risk Phrases ]:
23/24/25

[ Safety Phrases ]:
22-36/37/39-45

[ RIDADR ]:
UN 2811

[ RTECS ]:
FH4585000

Articles

Rapid detection of convallatoxin using five digoxin immunoassays.

Clin. Toxicol. (Phila.) 52(7) , 659-63, (2014)

Cardiac glycosides of plant origin are implicated in toxic ingestions that may result in hospitalization and are potentially lethal. The utility of commonly available digoxin serum assays for detectin...

PBI-05204, a supercritical CO₂ extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway.

Invest. New Drugs 33(2) , 271-9, (2015)

Introduction Oleandrin, a cardiac glycoside, exerts strong anti-proliferative activity against various human malignancies in in vitro cells. Here, we report the antitumor efficacy of PBI-05204, a supe...

BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.

J. Neurosci. 34(3) , 963-8, (2014)

We have previously shown that the botanical drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, provides neuroprotection in both in vitro and in vivo brain slice-based models for...

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