Bufalin
Suppliers
Names
[ CAS No. ]:
465-21-4
[ Name ]:
Bufalin
[Synonym ]:
3,14-dihydroxybufa-20,22-dienolide
(3β,5β)-3,14-Dihydroxybufa-20,22-dienolide
Bufalin: Bufa-20,22-dienolide, 3,14-dihydroxy-, (3b,5b)-,
Bufa-20,22-dienolide, 3,14-dihydroxy-, (3β,5β)-
5β-Bufa-20,22-dienolide, 3β,14-dihydroxy-
3β,14β-dihydroxy-5β-bufa-20,22-dienolide
(3b,5b)-3,14-Dihydroxybufa-20,22-dienolide
Bufalin
MFCD00056525
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
556.6±50.0 °C at 760 mmHg
[ Melting Point ]:
242 - 243ºC
[ Molecular Formula ]:
C24H34O4
[ Molecular Weight ]:
386.524
[ Flash Point ]:
189.0±23.6 °C
[ Exact Mass ]:
386.245697
[ PSA ]:
70.67000
[ LogP ]:
3.42
[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C
[ Index of Refraction ]:
1.594
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EI2962500
- CHEMICAL NAME :
- 5-beta-Bufa-20,22-dienolide, 3-beta,14-dihydroxy-
- CAS REGISTRY NUMBER :
- 465-21-4
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C24-H34-O4
- MOLECULAR WEIGHT :
- 386.58
- WISWESSER LINE NOTATION :
- L E5 B666TJ A1 E1 IQ OQ F- ET6OVJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 740 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 140 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,189,1963
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 137 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 24,222,1949
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300
[ Precautionary Statements ]:
P264-P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
R28
[ Safety Phrases ]:
28-36/37-45
[ RIDADR ]:
UN 3462
[ WGK Germany ]:
3
[ RTECS ]:
EI2962500
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
Articles
Am. J. Chin. Med. 42(3) , 729-42, (2014)
Bufalin is a key component of a Chinese medicine (Chan Su) and has been proved effective in killing various cancer cells. Its role in inducing DNA damage and the inhibition of the DNA damage response ...
Sci. Rep. 5 , 17047, (2015)
Sodium taurocholate cotransporting polypeptide (NTCP) has been reported as a functional receptor for hepatitis B virus (HBV) infection. However, HBV could not efficiently infect HepG2 cells expressing...
J. Tradit. Chin. Med. 34(6) , 678-83, (2014)
To probe insights into the reversal effect of bufalin on vincristine-acquired multidrug resistance (MDR) in human leukemia cell line K562/VCR.Proliferative inhibition rate and the reversal index (RI) ...