doxylamine

Suppliers

Names

[ CAS No. ]:
469-21-6

[ Name ]:
doxylamine

[Synonym ]:
Dossilamina
N,N-Dimethyl-2-[(1R)-1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine
Doxylaminum
doxilamina
Ethanamine, N,N-dimethyl-2-[(1R)-1-phenyl-1-(2-pyridinyl)ethoxy]-
N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
Doxilminio

Chemical & Physical Properties

[ Density]:
1.043 g/cm3

[ Boiling Point ]:
364.9ºC at 760 mmHg

[ Melting Point ]:
25°C

[ Molecular Formula ]:
C17H22N2O

[ Molecular Weight ]:
270.37

[ Flash Point ]:
174.5ºC

[ Exact Mass ]:
270.17300

[ PSA ]:
25.36000

[ LogP ]:
2.92330

[ Index of Refraction ]:
1.5486 (estimate)

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US9250000
CHEMICAL NAME :
Pyridine, 2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl )-
CAS REGISTRY NUMBER :
469-21-6
BEILSTEIN REFERENCE NO. :
0230379
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C17-H22-N2-O
MOLECULAR WEIGHT :
270.41
WISWESSER LINE NOTATION :
T6NJ BX1&R&O2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
440 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(5),17,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
470 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(5),17,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
460 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(5),17,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
62 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(5),17,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
REFERENCE :
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(5),17,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
49 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
REFERENCE :
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(5),17,1982

Synthetic Route

Click to get detail synthetic route

Related Compounds

  • Doxylamine-d5
  • Doxylamine N-Oxide
  • Doxylamine N-oxide
  • DOXYLAMINE SUCCINATE
  • Desmethyl Doxylamine
  • Doxylamine di-N-Oxide
  • Ethyl 2-(benzo[b]thiophen-3-yl)-2-(dimethylamino)acetate
  • Ethyl 2-(dimethylamino)-2-(naphthalen-1-yl)acetate
  • 4-[4-Chloro-3-(trifluoromethyl)phenoxy]-3-fluorobenzoic acid
  • (2S)-6-fluoro-5-[3-(8-fluoro-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)-2-methylphenyl]-2-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide
  • Benzonitrile, 2,5-difluoro-4-[(4-fluoro-2,3-dihydro-7-benzofuranyl)oxy]-
  • Tert-butyl 4-[3-chloro-4-(trifluoromethyl)phenoxy]-2,5-difluorobenzoate
  • N-(3-Bromo-2-methylphenyl)-3-chloro-2-pyridineacetamide
  • 3-(3-Bromo-2-methylphenyl)-1-methyl-2,4(1H,3H)-quinazolinedione
  • 4-bromo-7-(ethoxycarbonyl)-3-fluoro-9H-carbazole-1-carboxylic acid
  • 3-(3-Bromo-2-methylphenyl)-2,4(1H,3H)-quinazolinedione
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.