Marinobufogenin

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Names

[ CAS No. ]:
470-42-8

[ Name ]:
Marinobufogenin

[Synonym ]:
(3β,5β,15β)-3,5-Dihydroxy-14,15-epoxybufa-20,22-dienolide
5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,5-dihydroxy-
5beta-Bufa-20,22-dienolide,14,15beta-epoxy-3beta,5-dihydroxy
Bufa-20,22-dienolide,14,15-epoxy-3,5-dihydroxy-,(3beta,5beta,15beta)
Marinobufagenin
Marinobufogenin
Marinobufagin
Bufa-20,22-dienolide, 14,15-epoxy-3,5-dihydroxy-, (3β,5β,15β)-
MARCINOBUFAGIN
5-hydroxyl-resibufogenin

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
589.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₃₂O₅

[ Molecular Weight ]:
400.508

[ Flash Point ]:
203.0±23.6 °C

[ Exact Mass ]:
400.224976

[ PSA ]:
83.20000

[ LogP ]:
1.25

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.621

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI2963000

CHEMICAL NAME :: 5-beta-Bufa-20,22-dienolide, 3-beta,5-dihydroxy-14,15-beta-epoxy-

CAS REGISTRY NUMBER :: 470-42-8

LAST UPDATED :: 199009

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C24-H32-O5

MOLECULAR WEIGHT :: 400.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2730 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 152 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1520 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,111,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 556 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,192,1963

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds

1-Acetyl-4-chloro-1,2-dihydro-2-methyl-3H-indol-3-one
Pyrimidine, 4-(1H-imidazol-2-yl)-2-(1-pyrrolidinyl)-
3-(1,1-Dimethylethyl)-1-phenyl-4-[2-(3-phenyl-1,2,4-thiadiazol-5-yl)diazenyl]-1H-pyrazol-5-amine
Pyrimidine, 4-[[4-(1-methylethyl)phenyl]thio]-
Poly(oxy-1,2-ethanediyl), I+/--[1-oxo-3-[[[(phenylmethyl)thio]thioxomethyl]thio]propyl]-I-methoxy-
Acetamide, 2-[(cyclopentylmethyl)thio]-N-ethyl-
Ethyl (2S)-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate
4,5-Dimethoxy-2-(2-methoxyethenyl)benzonitrile
[1,1a(2)-Biphenyl]-3-carboxylic acid, 2-methoxy-4a(2)-(trifluoromethoxy)-, methyl ester
1,3-Dioxane-4,6-dione, 5-[(3,4-dihydro-6-methoxy-2H-1-benzopyran-3-yl)carbonyl]-2,2-dimethyl-

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