Cineole
Suppliers
Names
[ CAS No. ]:
470-82-6
[ Name ]:
Cineole
[Synonym ]:
2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane
eucalyptol (cineole)
Terpan
2-Oxabicyclo[2.2.2]octane, 1,3,3-trimethyl-
2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane
Eucapur
Zineol
Eukalyptol [Czech]
p-Menthane, 1,8-epoxy-
Eucalyptol
Eucalyptole
MFCD00167977
1,8-Cineol
1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane,1,8-Cineole,1,8-Epoxy-p-menthane
EINECS 207-431-5
1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octane
cineole
Cajeputol
1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane
1,8-cineole
1,8-Epoxy-p-menthane
limonene oxide
p-Cineole
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
174.0±8.0 °C at 760 mmHg
[ Melting Point ]:
1.5ºC
[ Molecular Formula ]:
C10H18O
[ Molecular Weight ]:
154.249
[ Flash Point ]:
50.9±15.3 °C
[ Exact Mass ]:
154.135757
[ PSA ]:
9.23000
[ LogP ]:
2.82
[ Vapour Pressure ]:
1.6±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.461
[ Stability ]:
Stable. Flammable. Incompatible with acids, bases, strong oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OS9275000
- CHEMICAL NAME :
- p-Menthane, 1,8-epoxy-
- CAS REGISTRY NUMBER :
- 470-82-6
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C10-H18-O
- MOLECULAR WEIGHT :
- 154.28
- WISWESSER LINE NOTATION :
- T66 A B AOTJ B1 B1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2480 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - coma
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1070 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, other (after systemic exposure)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2250 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2 gm/kg
- SEX/DURATION :
- female 19-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - biochemical and metabolic
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 200 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** TOXICOLOGY REVIEW DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(4),10,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 19540 No. of Facilities: 1103 (estimated) No. of Industries: 11 No. of Occupations: 23 No. of Employees: 5213 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 19540 No. of Facilities: 4397 (estimated) No. of Industries: 48 No. of Occupations: 57 No. of Employees: 83399 (estimated) No. of Female Employees: 20158 (estimated)
Safety Information
[ Symbol ]:
GHS02
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226
[ Precautionary Statements ]:
P210-P370 + P378
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R10;R37/38;R41
[ Safety Phrases ]:
S26-S39
[ RIDADR ]:
UN 1993
[ WGK Germany ]:
2
[ RTECS ]:
OS9275000
[ Packaging Group ]:
III
[ Hazard Class ]:
3.0
Synthetic Route
Precursor & DownStream
Precursor
DownStream
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