Ethane,1,1'-sulfonylbis[2-chloro-

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Names

[ CAS No. ]:
471-03-4

[ Name ]:
Ethane,1,1'-sulfonylbis[2-chloro-

[Synonym ]:
sulfur mustard sulfone
Mustard gas sulfone
Sulfone,bis(2-chloroethyl)
1,1'-Sulphonylbis(2-chloroethane)
Bis(2-chloroethyl) sulfone
Yperite sulfone
mustard sulfone
H sulfone

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Boiling Point ]:
340.8ºC at 760 mmHg

[ Molecular Formula ]:
C4H8Cl2O2S

[ Molecular Weight ]:
191.07600

[ Flash Point ]:
159.9ºC

[ Exact Mass ]:
189.96200

[ PSA ]:
42.52000

[ LogP ]:
1.95960

[ Vapour Pressure ]:
0.000166mmHg at 25°C

[ Index of Refraction ]:
1.476

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WR3325000
CHEMICAL NAME :
Sulfone, bis(2-chloroethyl)
CAS REGISTRY NUMBER :
471-03-4
BEILSTEIN REFERENCE NO. :
1759251
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C4-H8-Cl2-O2-S
MOLECULAR WEIGHT :
191.08
WISWESSER LINE NOTATION :
G2SW2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,1,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>72 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,1,1948
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 43,171,1952
TYPE OF TEST :
LC - Lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,Jan,1942
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,1,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,1,1948
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1430 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,JAN1942
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1430 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,JAN1942

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethane,1,1'-sulfinylbis[2-chloro-
  • Mustard gas
  • 2-Chloroethyl ethyl sulfide
  • N,N′-DICHLOROBIS(2,4,6-TRICHLOROPHENYL) UREA
  • DIETHYL SULFONE
  • nitric acid
  • Chlorosulfonic acid
  • Perbenzoic acid
  • Chloroform
  • Hydrogen peroxide

DownStream

  • Thiomorpholine,4-phenyl-, 1,1-dioxide
  • Divinyl sulfone
  • 2-CHLOROETHYLVINYLSULPHONE
  • Ethyl 2-(1, 1-dioxidothiomorpholino)acetate
  • 2-(1,1-DIOXIDOTHIOMORPHOLINO)-3-PHENYLPROPANOIC ACID
  • 1,4-Thioxane-1,1-dioxide
  • 2,2'-Sulfonyldiethanol
  • 2-(2-phenoxyethylsulfonyl)ethoxybenzene
  • 1,4-dithiane 1,1-dioxide
  • Thiomorpholine,4-methyl-, 1,1-dioxide

Related Compounds

  • Benzene,1,1'-sulfonylbis[2-chloro-4-isothiocyanato-
  • 1-methoxy-2-(2-methoxyethylsulfonyl)ethane
  • 1-methylsulfinyl-2-(2-methylsulfinylethylsulfonyl)ethane
  • Ethane,1,1'-sulfinylbis[2-chloro-
  • Ethane,1,1',1''-[methylidynetris(oxy)]tris[2-chloro-
  • Aziridine,1,1'-sulfonylbis[2-methyl-
  • 2-((3-(4-ethoxyphenyl)-4-oxo-7-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)thio)-N-(4-methylbenzyl)acetamide
  • C27H28N4O4S
  • 2-((3-chlorobenzyl)thio)-7-phenyl-3-(p-tolyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
  • N-(3-Methoxypropyl)-N-methyl-4-prop-2-ynylpiperazine-1-carboxamide
  • 2-((2,5-dimethylbenzyl)thio)-7-phenyl-3-(p-tolyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
  • 2-((4-isopropylbenzyl)thio)-7-phenyl-3-(p-tolyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
  • 1-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-4-(4-methoxyphenyl)-1H,2H,3H,4H,5H,7H-furo[3,4-d]pyrimidine-2,5-dione
  • 2-[2-(4-Fluorophenyl)-3-(hydroxymethyl)-4-oxo-4H,5H-pyrazolo[1,5-A]pyrazin-5-YL]-N-(4-methylphenyl)acetamide
  • Ethyl 4-ethenyl-2-(oxan-2-ylmethoxy)pyridine-3-carboxylate
  • N-(4-fluorophenyl)-2-[2-(4-fluorophenyl)-3-(hydroxymethyl)-4-oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl]acetamide
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