Propiolic acidd

Names

[ CAS No. ]:
471-25-0

[ Name ]:
Propiolic acidd

[Synonym ]:
prop-2-ynoic acid
propargylic acid
Propynoic acid
2-propynoic acid
Propiolic acid
MFCD00004360
Acetylenecarboxylic acid
Propiolic Acidd
EINECS 207-437-8

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
139.7±0.0 °C at 760 mmHg

[ Melting Point ]:
16-18 °C(lit.)

[ Molecular Formula ]:
C₃H₂O₂

[ Molecular Weight ]:
70.047

[ Flash Point ]:
58.9±0.0 °C

[ Exact Mass ]:
70.005478

[ PSA ]:
37.30000

[ LogP ]:
0.31

[ Vapour Pressure ]:
3.7±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.456

[ Stability ]:
Stable. Incompatible with bases, oxidizing agents, reducing agents. Combustible.

[ Water Solubility ]:
miscible

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UD9300000

CHEMICAL NAME :: Propiolic acid

CAS REGISTRY NUMBER :: 471-25-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C3-H2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H301-H310-H314

[ Precautionary Statements ]:
P280-P302 + P350-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S24/25

[ RIDADR ]:
UN 2920 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
UD9300000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
29161980

Precursor & DownStream

Precursor

Propargyl alcohol
2-Butynedioic acid
2-Butenedioic acid,2-bromo-, (2E)-
2-Butenedioic acid,2-bromo-, (2Z)-
sodium acetylide
Bromo(ethynyl)magnesium
sodium monoacetylide
Carbon dioxide
n-Butyllithium
bromoethene

DownStream

Ethylamine
Glycine
DL-Alanine
methylamine
hexa-2,4-diynedioic acid
4-[1,2,3]Triazol-1-Yl-Benzaldehyde
Trimesic acid
(2E)-3-Cyclohexylprop-2-enoic acid
3-cyclohexylprop-2-enoic acid
Daphnetin

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Identification of the toxic trigger in mushroom poisoning.

Nat. Chem. Biol. 5 , 465-7, (2009)

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a...

Hierarchically functionalized magnetic core/multishell particles and their postsynthetic conversion to polymer capsules.

ACS Nano 9 , 4219-26, (2015)

The controlled synthesis of hierarchically functionalized core/multishell particles is highly desirable for applications in medicine, catalysis, and separation. Here, we describe the synthesis of hier...

Development of a tailor-made bis(oxazolidine)pyridine-metal catalyst for the [3+2] cycloaddition of azomethine imines with propiolates.

Chem. Commun. (Camb.) 49(71) , 7776-8, (2013)

A series of bis(oxazolidine)pyridine ligands (the PyBodines) were newly designed and synthesized for the development of a highly efficient, tailor-made catalyst for the [3+2] cycloaddition of azomethi...