Propiolic acidd

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Names

[ CAS No. ]:
471-25-0

[ Name ]:
Propiolic acidd

[Synonym ]:
prop-2-ynoic acid
propargylic acid
Propynoic acid
2-propynoic acid
Propiolic acid
MFCD00004360
Acetylenecarboxylic acid
Propiolic Acidd
EINECS 207-437-8

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
139.7±0.0 °C at 760 mmHg

[ Melting Point ]:
16-18 °C(lit.)

[ Molecular Formula ]:
C3H2O2

[ Molecular Weight ]:
70.047

[ Flash Point ]:
58.9±0.0 °C

[ Exact Mass ]:
70.005478

[ PSA ]:
37.30000

[ LogP ]:
0.31

[ Vapour Pressure ]:
3.7±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.456

[ Stability ]:
Stable. Incompatible with bases, oxidizing agents, reducing agents. Combustible.

[ Water Solubility ]:
miscible

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UD9300000
CHEMICAL NAME :
Propiolic acid
CAS REGISTRY NUMBER :
471-25-0
LAST UPDATED :
199709
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C3-H2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H301-H310-H314

[ Precautionary Statements ]:
P280-P302 + P350-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S24/25

[ RIDADR ]:
UN 2920 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
UD9300000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
29161980

Precursor & DownStream

Precursor

  • Propargyl alcohol
  • 2-Butynedioic acid
  • 2-Butenedioic acid,2-bromo-, (2E)-
  • 2-Butenedioic acid,2-bromo-, (2Z)-
  • sodium acetylide
  • Bromo(ethynyl)magnesium
  • sodium monoacetylide
  • Carbon dioxide
  • n-Butyllithium
  • bromoethene

DownStream

  • Ethylamine
  • Glycine
  • DL-Alanine
  • methylamine
  • hexa-2,4-diynedioic acid
  • 4-[1,2,3]Triazol-1-Yl-Benzaldehyde
  • Trimesic acid
  • (2E)-3-Cyclohexylprop-2-enoic acid
  • 3-cyclohexylprop-2-enoic acid
  • Daphnetin

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Identification of the toxic trigger in mushroom poisoning.

Nat. Chem. Biol. 5 , 465-7, (2009)

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a...

Hierarchically functionalized magnetic core/multishell particles and their postsynthetic conversion to polymer capsules.

ACS Nano 9 , 4219-26, (2015)

The controlled synthesis of hierarchically functionalized core/multishell particles is highly desirable for applications in medicine, catalysis, and separation. Here, we describe the synthesis of hier...

Development of a tailor-made bis(oxazolidine)pyridine-metal catalyst for the [3+2] cycloaddition of azomethine imines with propiolates.

Chem. Commun. (Camb.) 49(71) , 7776-8, (2013)

A series of bis(oxazolidine)pyridine ligands (the PyBodines) were newly designed and synthesized for the development of a highly efficient, tailor-made catalyst for the [3+2] cycloaddition of azomethi...


More Articles


Related Compounds

  • propiolic acid , ammonium compound
  • Propiolic acid beta-naphthyl methyl ester
  • Propiolic acid, (m-chlorophenyl)- (8CI)
  • Propiolic Acid Sodium Salt
  • cyclohexyl-propiolic acid amide
  • iodo-propiolic acid
  • N-{2-[(2R)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-2-oxoethyl}-N-methylprop-2-enamide
  • N-ethyl-N-({[(1S)-1-(3-fluoropyridin-2-yl)ethyl]carbamoyl}methyl)prop-2-enamide
  • tert-butyl (1S,4S)-5-[2-(N-ethylprop-2-enamido)acetyl]-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
  • 1-[4-(2,3-Dihydroimidazo[1,2-a]imidazole-1-carbonyl)piperidin-1-yl]prop-2-en-1-one
  • N-{2-[4-(2-cyano-4-fluorophenyl)piperazin-1-yl]-2-oxoethyl}-N-ethylprop-2-enamide
  • Tert-butyl N-[2-methyl-4-[(1-prop-2-enoylpiperidine-4-carbonyl)amino]butan-2-yl]carbamate
  • tert-butyl 2-[2-(N-ethylprop-2-enamido)acetyl]-2,6-diazaspiro[3.5]nonane-6-carboxylate
  • N-Ethyl-N-[2-[4-(oxan-4-ylamino)piperidin-1-yl]-2-oxoethyl]prop-2-enamide
  • N-[(2R)-1-Methoxypropan-2-yl]-N-methyl-1-prop-2-enoylpiperidine-4-carboxamide
  • N-[2-(7,8-Dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-2-oxoethyl]-N-methylprop-2-enamide
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