Telocinobufagin

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Names

[ CAS No. ]:
472-26-4

[ Name ]:
Telocinobufagin

[Synonym ]:
3,5,14-Trihydroxybufa-20,22-dienolide
Telobufotoxin
5β-Bufa-20,22-dienolide, 3β,5,14-trihydroxy-
Telecinobufagin
Telocinobufogenin
(3β,5β)-3,5,14-Trihydroxybufa-20,22-dienolide
Bufa-20,22-dienolide, 3,5,14-trihydroxy-, (3β,5β)-
Telocinobufagin

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
589.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H34O5

[ Molecular Weight ]:
402.524

[ Flash Point ]:
201.0±23.6 °C

[ Exact Mass ]:
402.240631

[ PSA ]:
90.90000

[ LogP ]:
1.78

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.624

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EI2996700
CHEMICAL NAME :
5-beta-Bufa-20,22-dienolide, 3-beta,5,14-trihydroxy-
CAS REGISTRY NUMBER :
472-26-4
BEILSTEIN REFERENCE NO. :
0056287
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C24-H34-O5
MOLECULAR WEIGHT :
402.58
WISWESSER LINE NOTATION :
L E5 B666TJ A1 E1 IQ MQ OQ F- ET6OVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4340 ug/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
102 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,194,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1102 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethanol
  • acetic acid
  • Marinobufogenin

DownStream

Related Compounds

  • 5-bromo-N-methyl-N-(1-{3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}azetidin-3-yl)pyrimidin-2-amine
  • 5-fluoro-N-methyl-N-(1-{3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}azetidin-3-yl)pyrimidin-2-amine
  • 4-[(3,5-Dimethylpiperidin-1-yl)sulfonyl]benzene-1-sulfonamide
  • 7-(1,1-Dimethylethyl) 3-methyl 5,6-dihydroimidazo[1,2-a]pyrazine-3,7(8H)-dicarboxylate
  • N-(3,4-dimethoxyphenyl)-2-((3-(4-fluorobenzyl)-4-oxo-3,4-dihydrobenzofuro[3,2-d]pyrimidin-2-yl)thio)acetamide
  • 1,1-Dimethylethyl 5,6-dihydro-3-(1-hydroxy-1-methylethyl)imidazo[1,2-a]pyrazine-7(8H)-carboxylate
  • acetic 4-((3-methyl-1,1-dioxido-4H-benzo[e][1,2,4]thiadiazin-4-yl)methyl)benzoic anhydride
  • 1,1-Dimethylethyl 5,6-dihydro-3-(1-hydroxyethyl)-1,2,4-triazolo[4,3-a]pyrazine-7(8H)-carboxylate
  • 2-(4-acetylphenyl)-4-(2,4-dimethylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide
  • 1,1-Dimethylethyl 5,6-dihydro-3-(methylsulfonyl)-1,2,4-triazolo[4,3-a]pyrazine-7(8H)-carboxylate
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