3alpha-amino-5alpha-pregnan-20-one

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Names

[ CAS No. ]:
474-45-3

[ Name ]:
3alpha-amino-5alpha-pregnan-20-one

[Synonym ]:
Amafolona [INN-Spanish]
(2beta,3alpha,5alpha)-3-Amino-2-hydroxyandrostan-17-one,hydrochloride
Amafolonum
Amafolona
Amafolone
Amafolonum [INN-Latin]

Chemical & Physical Properties

[ Density]:
1.014g/cm3

[ Boiling Point ]:
419.9ºC at 760mmHg

[ Molecular Formula ]:
C21H35NO

[ Molecular Weight ]:
317.50900

[ Flash Point ]:
207.8ºC

[ Exact Mass ]:
317.27200

[ PSA ]:
43.09000

[ LogP ]:
5.26190

[ Vapour Pressure ]:
2.93E-07mmHg at 25°C

[ Index of Refraction ]:
1.516

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4375000
CHEMICAL NAME :
5-alpha-Pregnan-20-one, 3-alpha-amino-
CAS REGISTRY NUMBER :
474-45-3
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H35-N-O
MOLECULAR WEIGHT :
317.57
WISWESSER LINE NOTATION :
L E5 B666TJ A1 E1 FV1 OZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 274,2830,1972
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 18,177,1960

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds

  • (20S)-3alpha-amino-5alpha-pregnan-20-ol
  • 3alpha,17,21-trihydroxy-5alpha-pregnan-20-one
  • Posovolone
  • 3-hydroxypregnan-3-one 3-sulfate
  • Pregnan-20-one,3,21-bis(acetyloxy)-11-hydroxy-, (3a,5b,11b)- (9CI)
  • 5alpha-Pregnan-3alpha-ol-20-one
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • tert-butyl N-{[(1r,3r)-3-(benzyloxy)-1-(hydroxymethyl)cyclobutyl]methyl}carbamate
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • (2S)-3-({1-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopropyl}formamido)-2-hydroxypropanoic acid
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine