GLYCOLANILIDE

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Names

[ CAS No. ]:
4746-61-6

[ Name ]:
GLYCOLANILIDE

[Synonym ]:
N-Phenyl-2-hydroxyacetamide
glycolic acid N-phenylamide
A-3-Hydroxyacetanilide
2-hydroxyacetanilide
HOCH2CONHPh
hydroxyacetanilide
Hydroxyacetylaminobenzene
Glycolanilide

Chemical & Physical Properties

[ Density]:
1.259g/cm3

[ Boiling Point ]:
373.4ºC at 760 mmHg

[ Molecular Formula ]:
C8H9NO2

[ Molecular Weight ]:
151.16300

[ Flash Point ]:
179.7ºC

[ Exact Mass ]:
151.06300

[ PSA ]:
49.33000

[ LogP ]:
0.69040

[ Index of Refraction ]:
1.618

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC3851000
CHEMICAL NAME :
Acetamide, 2-hydroxy-N-phenyl-
CAS REGISTRY NUMBER :
4746-61-6
BEILSTEIN REFERENCE NO. :
1210581
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C8-H9-N-O2
MOLECULAR WEIGHT :
151.18
WISWESSER LINE NOTATION :
Q1VMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
14286 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 35,50,1946
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 35,50,1946
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 35,50,1946

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • glycolamide
  • Glycolic acid
  • 2-N,4-N,1,3-tetraphenyl-1,3,2,4-diazadiphosphetidine-2,4-diamine
  • 2,2-dimethyl-1,3-dioxolan-4-one
  • Carbon dioxide
  • p-Toluidine

DownStream

  • Acetamide,N-(4-bromophenyl)-2-hydroxy-
  • N,N'-Diphenylethanediamide
  • 2,4-Dinitrophenol
  • 2,4-Dinitrodiphenylamine
  • 2-(2,4-dinitrophenoxy)-N-phenylacetamide
  • 2-chloroacetanilide
  • Acetamide,2-(acetyloxy)-N-phenyl-

Related Compounds

  • Glycolanilide
  • N-methyl glycolanilide
  • 4'-(5-(p-Aminophenoxy)pentyloxy)glycolanilide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 2-Chloro-4-propoxypyrimidin-5-amine
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 5-Methyl-3-(3-phenoxyphenyl)isoxazole-4-carboxylic acid
  • Methyl 2-chloro-5-ethyl-5-methyl-1,6-dioxaspiro[2.5]octane-2-carboxylate
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde