1,3-Dioxolo[4,5-b]acridin-10(5H)-one,4,11-dimethoxy-5-methyl-

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Names

[ CAS No. ]:
475-91-2

[ Name ]:
1,3-Dioxolo[4,5-b]acridin-10(5H)-one,4,11-dimethoxy-5-methyl-

[Synonym ]:
2,3-Methandiyldioxy-1,4-dimethoxy-N-methyl-acridon
melicopidine
Melicopidin
EINECS 207-502-0

Chemical & Physical Properties

[ Density]:
1.345g/cm3

[ Boiling Point ]:
530.4ºC at 760 mmHg

[ Molecular Formula ]:
C17H15NO5

[ Molecular Weight ]:
313.30500

[ Flash Point ]:
274.6ºC

[ Exact Mass ]:
313.09500

[ PSA ]:
58.92000

[ LogP ]:
2.43760

[ Vapour Pressure ]:
2.48E-11mmHg at 25°C

[ Index of Refraction ]:
1.619

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JI4630000
CHEMICAL NAME :
1,3-Dioxolo(4,5-b)acridin-10(5H)-one, 4,11-dimethoxy-5-methyl-
CAS REGISTRY NUMBER :
475-91-2
BEILSTEIN REFERENCE NO. :
0335565
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H15-N-O5
MOLECULAR WEIGHT :
313.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
LLOYA2 Lloydia. (Cincinnati, OH) V.1-41, 1938-78. For publisher information, see JNPRDF. Volume(issue)/page/year: 30,364,1967

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methyl iodide

DownStream

Related Compounds

  • 4-hydroxy-6-methoxy-N-[2-(pyridin-4-yl)ethyl]quinoline-3-carboxamide
  • 4-bromo-5-(2-bromo-4,5-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid
  • 4-hydroxy-8-methoxy-N-(1H-tetrazol-5-yl)quinoline-3-carboxamide
  • 4-chloro-2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
  • N-(6-bromo-5-chloropyridin-2-yl)benzamide
  • N-[3-(4-methoxybenzyl)-1H-1,2,4-triazol-5-yl]-4-([1,2,4]triazolo[4,3-a]pyridin-3-yl)butanamide
  • Boh (drug), (R)-
  • methyl N-{[3-(naphthalen-1-yl)-6-oxopyridazin-1(6H)-yl]acetyl}glycinate
  • 2-(4-fluorophenyl)-N-{3-[2-(1H-indol-3-yl)ethyl]-1H-1,2,4-triazol-5-yl}acetamide
  • Ethyl 1-(4-benzylpiperazin-1-yl)cyclopropanecarboxylate
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