1,4-Dichlorophthalazine

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Names

[ CAS No. ]:
4752-10-7

[ Name ]:
1,4-Dichlorophthalazine

[Synonym ]:
1,4-dichlorophtalazine
MFCD00006909
EINECS 225-275-6
1,4-dichloronaphthazine
1,2-dichlorophthalazine
Phthalazine, 1,4-dichloro-
Phthalazine,1,4-dichloro
1,4-Dichlorophthalazine

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
397.3±22.0 °C at 760 mmHg

[ Melting Point ]:
160-162 °C(lit.)

[ Molecular Formula ]:
C8H4Cl2N2

[ Molecular Weight ]:
199.037

[ Flash Point ]:
226.4±7.9 °C

[ Exact Mass ]:
197.975159

[ PSA ]:
25.78000

[ LogP ]:
2.13

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.671

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,3-Dihydrophthalazine-1,4-dione
  • Phthalic anhydride
  • aminophthalimide
  • Phthalazine
  • methyl 2-(chlorocarbonyl)benzoate
  • Phthalic acid
  • [2,2'-Bi-2H-isoindole]-1,1',3,3'-tetrone
  • phosphoryl trichloride

DownStream

  • 4-HYDRAZINYLPHTHALAZIN-1(2H)-ONE
  • Phthalonitrile
  • dihydralazine
  • 1-chloro-4-methoxyphthalazine
  • 1-ETHOXY-4-CHLOROPHTHALAZINE
  • N,N-bis[(2-chlorophenyl)methylideneamino]phthalazine-1,4-diamine
  • Benzaldehyde, 2,6-dichloro-, 1,4-phthalazinediyldihydrazone(8CI,9CI)
  • 2-Propenal, 3-phenyl-,1,4-phthalazinediyldihydrazone (9CI)
  • Benzaldehyde, 3-nitro-,1,4-phthalazinediyldihydrazone (9CI)
  • Benzaldehyde,4-chloro-, 1,4-phthalazinediyldihydrazone (9CI)

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.

J. Med. Chem. 50 , 3627, (2007)

A series of exceptionally potent agonists at neuronal nicotinic acetylcholine receptors (nAChRs) has been investigated. Several N-(3-pyridinyl) derivatives of bridged bicyclic diamines exhibit double-...

Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II.

Bioorg. Med. Chem. Lett. 16 , 1579, (2006)

A novel class of 1-(isoquinolin-5-yl)-4-arylamino-phthalazines is described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Many compounds display VEGFR-2 inhibitory activit...

Discrimination of reactively-dyed cotton fibres with thin layer chromatography and UV microspectrophotometry.

Sci. Justice 55 , 422-30, (2015)

Reactively-dyed black, navy blue and medium red cotton samples showing metamerism under fluorescent tube illumination were examined. Optical microscopy (bright field, polarization and fluorescence mic...


More Articles

Related Compounds

  • 6-cyano-1,4-dichlorophthalazine
  • 6-bromo-1,4-dichlorophthalazine
  • 1,4-dichlorophthalazine-6-carbonyl chloride
  • 1-(4-hydroxy-3-methylnaphthalen-1-yl)ethanone
  • 1-(4-Aminobutyl)-4-(diphenylmethyl)piperazine
  • 1-[4-(benzenesulfonyl)phenoxy]naphthalene