5-chloro-1-[3-(dimethylamino)propyl]-3-phenylbenzimidazol-2-one

Names

[ Name ]:
5-chloro-1-[3-(dimethylamino)propyl]-3-phenylbenzimidazol-2-one

[Synonym ]:
Clodazone
Clodazone [INN-French]
5-chloro-1-(3-dimethylamino-propyl)-3-phenyl-1,3-dihydro-benzoimidazol-2-one
Clodazon [INN]
CLODAZON
2-Benzimidazolinone,5-chloro-1-(3-(dimethylamino)propyl)-3-phenyl
Clodazona [INN-Spanish]
5-Chloro-1-(3-(dimethylamino)propyl)-3-phenyl-2-benzimidazolinone
Clodazonum [INN-Latin]

Chemical & Physical Properties

[ Density]:
1.232g/cm3

[ Boiling Point ]:
466.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₂₀ClN₃O

[ Molecular Weight ]:
329.82400

[ Flash Point ]:
235.8ºC

[ Exact Mass ]:
329.12900

[ PSA ]:
30.17000

[ LogP ]:
3.39730

[ Index of Refraction ]:
1.609

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE1800000

CHEMICAL NAME :: 2-Benzimidazolinone, 5-chloro-1-(3-(dimethylamino)propyl)-3-phenyl-

CAS REGISTRY NUMBER :: 4755-59-3

BEILSTEIN REFERENCE NO. :: 0894387

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H20-Cl-N3-O

MOLECULAR WEIGHT :: 329.86

WISWESSER LINE NOTATION :: T6MTJ DXQR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 142 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 77 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 715 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 505 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968

Related Compounds

(1R,2S)-1-Amino-1-[2-chloro-4-(trifluoromethyl)phenyl]propan-2-OL
5-Amino-2,6-dichloro-4(1h)-pyrimidinone
Methyl 4-hydroxy-3-iodo-5-methylbenzoate
methyl 1-methyl-5-(piperidin-2-yl)-1H-pyrazole-3-carboxylate
methyl 2-(1,5-dimethyl-1H-pyrazol-3-yl)-2-hydroxyacetate
4-Chloro-2-(3-methyl-5-isoxazolyl)phenol
Tert-butyl (1-(3-ethoxy-4-methoxyphenyl)-3-hydroxybutyl)carbamate
5-Acetyl-3-(3,5-dimethylphenylsulfonyl)indole-2-carboxyamide
5-(2-Hydroxy-5-methoxyphenyl)-1,3,4-oxadiazol-2(3H)-one
tert-butyl N-[4-oxo-4-(1,3-thiazol-2-yl)butyl]carbamate