5-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

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Names

[ CAS No. ]:
476473-97-9

[ Name ]:
5-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

[Synonym ]:
5-(CHLOROMETHYL)-2,2-DIFLUORO-2H-1,3-BENZODIOXOLE
5-chloromethyl-2,2-difluoro-1,3-benzodioxole
5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole
5-CHLOROMETHYL-2,2-DIFLUORO-BENZO[1,3]DIOXOLE

Chemical & Physical Properties

[ Molecular Formula ]:
C8H5ClF2O2

[ Molecular Weight ]:
206.57400

[ Exact Mass ]:
205.99500

[ PSA ]:
18.46000

[ LogP ]:
2.74690

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (2,2-Difluoro-1,3-benzodioxol-5-yl)methanol
  • Methyl tert-butyl ether
  • 2,2-Difluorobenzodioxole-5-carboxylic acid
  • 5-Bromo-2,2-difluorobenzodioxole
  • Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate
  • 2,2-Difluoro-1,3-benzodioxole-5-carbaldehyde

DownStream

  • 1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic acid
  • 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID HYDROCHLORIDE
  • Tezacaftor(VX-661)
  • 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 6-Fluoro-3-methyl-1-benzothiophene-2-sulfonamide
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide