AC-7954

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Names

[ CAS No. ]:
477313-09-0

[ Name ]:
AC-7954

[Synonym ]:
ac-7954

Chemical & Physical Properties

[ Boiling Point ]:
462.8ºC at 760 mmHg

[ Molecular Formula ]:
C19H21Cl2NO2

[ Molecular Weight ]:
366.28200

[ Flash Point ]:
233.7ºC

[ Exact Mass ]:
365.09500

[ PSA ]:
29.54000

[ LogP ]:
4.70210

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Unraveling the active conformation of urotensin II.

J. Med. Chem. 47 , 1652-61, (2004)

Urotensin II (U-II) is a disulfide-bridged undecapeptide recently identified as the ligand of an orphan G-protein-coupled receptor. Human U-II (H-Glu-Thr-Pro-Asp-cyclo[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH)...

Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954).

J. Med. Chem. 45 , 4950-4953, (2002)

A functional cell-based screen identified 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one hydrochloride (AC-7954, 1) as a nonpeptidic agonist of the urotensin-II receptor. Racemic 1 had ...


More Articles

Related Compounds

  • 2,3-Dibromo-5-fluoro-4-methylbenzoic acid
  • Tert-butyl 1-(hydroxymethyl)-5-methyl-3-azabicyclo[3.1.1]heptane-3-carboxylate
  • 2-{5-[(1S)-1-hydroxy-2-methoxyethyl]-1H-1,2,3-triazol-1-yl}acetamide
  • 1-[1-(3-Aminopropyl)cyclohexyl]-3-(2-methylpropyl)urea
  • 1-[3-(1-Aminocyclohexyl)propyl]-3-propylurea
  • 1-[3-(1-Aminocyclohexyl)propyl]-3-ethylurea
  • N-{2-[(5-chloropyridin-3-yl)oxy]ethyl}-N-methylcyclopropanamine
  • (2S,4S)-1-{2-ethyl-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]butanoyl}-4-hydroxypyrrolidine-2-carboxylic acid
  • ethyl 4-(aminomethyl)-3,4-dihydro-2H-1-benzopyran-6-carboxylate
  • N-ethoxy-N-(propan-2-yl)piperidin-3-amine
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