d-berbamine

Suppliers

Names

[ CAS No. ]:
478-61-5

[ Name ]:
d-berbamine

[Synonym ]:
6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol
MFCD00067632
E6 berbamine
BERBAMAN-12-OL,6,6',7-TRIMETHOXY-2,2'-DIMETHYL
6,7,6'-trimethoxy-2,2'-dimethyl-berbaman-12-ol
EINECS 207-523-5
d-berbamine
BERBAINE
Berbaman-12-ol, 6,6',7-trimethoxy-2,2'-dimethyl-
berberamine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
707.0±60.0 °C at 760 mmHg

[ Melting Point ]:
225°C

[ Molecular Formula ]:
C₃₇H₄₀N₂O₆

[ Molecular Weight ]:
608.723

[ Flash Point ]:
381.4±32.9 °C

[ Exact Mass ]:
608.288635

[ PSA ]:
72.86000

[ LogP ]:
3.89

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.602

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9450000

CHEMICAL NAME :: Berbamine

CAS REGISTRY NUMBER :: 478-61-5

BEILSTEIN REFERENCE NO. :: 0078902

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C37-H40-N2-O6

MOLECULAR WEIGHT :: 608.79

WISWESSER LINE NOTATION :: T-T66 CNT&J C1 HO1 IO- JT66 CNT&J C1 HO1 IO1 B1R DQ COR D1- B-18-J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,26,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,45,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17430 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,45,1983

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36

Related Compounds

D-3263
D-(tetrahydro-2,3,4-trihydroxy-5-oxofuran-2-yl)glycollic acid
D-HOMOCYSTEINESULFINIC ACID
D-allo-Heptose, 2,6-anhydro-4-deoxy-3-O-methyl-5-O-(phenylmethyl)-, 7-acetate
D-Galactitol, 3,6-anhydro-2-O-methyl-, triacetate
D-Glucitol, 1-deoxy-1-(methylamino)-, N-C10-16 acyl derivs.
1-(4-Methoxyphenyl)-2-[(4-methyl-4H-1,2,4-triazol-3-yl)thio]-1-propanone
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
2-[(5-bromopyridin-2-yl)sulfanyl]-N-(1-cyano-1-cyclopropylethyl)acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
[4-chloro-2-(1H-tetrazol-1-yl)phenyl]{4-[(4-fluorophenyl)sulfonyl]piperazin-1-yl}methanone