d-berbamine

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Names

[ CAS No. ]:
478-61-5

[ Name ]:
d-berbamine

[Synonym ]:
6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol
MFCD00067632
E6 berbamine
BERBAMAN-12-OL,6,6',7-TRIMETHOXY-2,2'-DIMETHYL
6,7,6'-trimethoxy-2,2'-dimethyl-berbaman-12-ol
EINECS 207-523-5
d-berbamine
BERBAINE
Berbaman-12-ol, 6,6',7-trimethoxy-2,2'-dimethyl-
berberamine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
707.0±60.0 °C at 760 mmHg

[ Melting Point ]:
225°C

[ Molecular Formula ]:
C37H40N2O6

[ Molecular Weight ]:
608.723

[ Flash Point ]:
381.4±32.9 °C

[ Exact Mass ]:
608.288635

[ PSA ]:
72.86000

[ LogP ]:
3.89

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.602

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DR9450000
CHEMICAL NAME :
Berbamine
CAS REGISTRY NUMBER :
478-61-5
BEILSTEIN REFERENCE NO. :
0078902
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C37-H40-N2-O6
MOLECULAR WEIGHT :
608.79
WISWESSER LINE NOTATION :
T-T66 CNT&J C1 HO1 IO- JT66 CNT&J C1 HO1 IO1 B1R DQ COR D1- B-18-J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,26,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,45,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17430 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,45,1983

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36

Related Compounds

  • D-3263
  • D-(tetrahydro-2,3,4-trihydroxy-5-oxofuran-2-yl)glycollic acid
  • D-HOMOCYSTEINESULFINIC ACID
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  • D-Galactitol, 3,6-anhydro-2-O-methyl-, triacetate
  • D-Glucitol, 1-deoxy-1-(methylamino)-, N-C10-16 acyl derivs.
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  • 4-chloro-N,N-dimethyl-3-(propylamino)benzene-1-sulfonamide
  • 1,4-dichloro-2-[(1E)-2,3,3,3-tetrafluoroprop-1-en-1-yl]benzene
  • 2-amino-4-(2,4-dimethyl-1H-imidazol-1-yl)butanoic acid
  • 2-(methylamino)-3-[3-(propan-2-yl)-1H-1,2,4-triazol-1-yl]propanamide
  • 3-(4-ethoxy-1H-pyrazol-1-yl)-2-(methylamino)propanamide
  • 2-Cyclopropanesulfonamido-1,3-thiazole-5-carboxylic acid
  • 1-(5-Chloropyridin-2-yl)-3-(dimethylamino)prop-2-en-1-one
  • 3-(2,3-Dihydroxypropyl)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
  • 2-Pyridinemethanamine, 3,5-dichloro-I+/--(1,1-dimethylethyl)-I+/--methyl-
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