(3,4-DIHYDRO-2H-PYRAN-2-YL)-METHYLAMINE

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Names

[ CAS No. ]:
4781-76-4

[ Name ]:
(3,4-DIHYDRO-2H-PYRAN-2-YL)-METHYLAMINE

[Synonym ]:
3,4-Dihydro-2H-pyran-2-methylamine
3,4-dihydro-2-aminomethyl-2h-pyra
4H-Pyran,2-aminomethyl-2,3-dihydro
2-Aminomethyl-2,3-dihydro-4H-pyran
2H-Pyran,3,4-dihydro-2-aminomethyl
C-(3,4-dihydro-2H-pyran-2-yl)-methylamine
2-aminomethyl-3,4-dihydro-2H-pyran
3,4-dihydro-2H-pyran-2-methanamine

Chemical & Physical Properties

[ Density]:
0.996 g/cm3

[ Boiling Point ]:
184.1ºC at 760 mmHg

[ Molecular Formula ]:
C6H11NO

[ Molecular Weight ]:
113.15800

[ Flash Point ]:
70.5ºC

[ Exact Mass ]:
113.08400

[ PSA ]:
35.25000

[ LogP ]:
1.33810

[ Index of Refraction ]:
1.474

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UP7750000
CHEMICAL NAME :
2H-Pyran, 3,4-dihydro-2-aminomethyl-
CAS REGISTRY NUMBER :
4781-76-4
BEILSTEIN REFERENCE NO. :
1362797
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H11-N-O
MOLECULAR WEIGHT :
113.18
WISWESSER LINE NOTATION :
T6O BUTJ F1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
180 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 ppm/6H/8D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 27,1,1970

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3,4-Dihydro-2H-pyran-2-carbaldehyde
  • 3,4-dihydro-2H-pyran-2-carboxamide
  • (3,4-dihydro-2H-pyran-2-yl)methyl methanesulfonate
  • 3,4-dihydro-2H-pyran-2-ylmethanol
  • 3,4-dihydro-2H-pyran-2-ylmethyl 3,4-dihydro-2H-pyran-2-carboxylate
  • 2H-Pyran-2-carboxylicacid, 3,4-dihydro-, ethyl ester
  • 2H-Pyran-2-carboxylicacid, 3,4-dihydro-, sodium salt (1:1)

DownStream

Related Compounds

  • (3,4-DIHYDRO-2H-PYRAN-2-YL)-METHYLAMINE
  • (3,4-dihydro-2H-pyran-2-yl)methyl methacrylate
  • (3,4-dihydro-2H-pyran-2-yl)methyl methanesulfonate
  • (3,4-dihydro-2H-pyran-2-yl)methyl acrylate
  • 3,4-dihydro-2H-pyran-2-yl(methoxy)phosphinate
  • (3,4-dihydro-2H-pyran-2-yl)-carbamic acid ethyl ester
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 2-(7,8-dimethoxy-2-oxo-1,2-dihydro-3H-3-benzazepin-3-yl)-N-[3-(trifluoromethyl)phenyl]acetamide
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide