4,4-Difluoro-3,3-dimethyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}- L-proline

Names

[ CAS No. ]:
478698-32-7

[ Name ]:
4,4-Difluoro-3,3-dimethyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}- L-proline

[Synonym ]:
(2S)-4,4-difluoro-3,3-dimethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
1-hydroxymethyl-4-(4-(1,1-dimethylethoxycarbonyl)piperazinyl)benzene
1-(tert-Butoxycarbonyl)-4-(4-hydroxymethylphenyl)piperazine
4,4-difluoro-3,3-dimethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
(2S)-4,4-difluoro-3,3-dimethyl-N-Boc-proline
4-[4-(methoxycarbonyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
1-(tert-butoxycarbonyl)-4-(4-methoxycarbonylphenyl)piperazine
4-(4-N-Boc-piperazinyl)benzyl alcohol
4-(4-methoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
Methyl 4-(N-Boc-N'-piperazinyl)benzoate
1-(tert-butoxycarbonyl)-4,4-difluoro-3,3-dimethylpyrrolidine-2-carboxylic acid
tert-butyl 4-(4-(methoxycarbonyl)phenyl)piperazine-1-carboxylate
tert-butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
348.6ºC at 760 mmHg

[ Molecular Formula ]:
C12H19F2NO4

[ Molecular Weight ]:
279.28000

[ Exact Mass ]:
279.12800

[ PSA ]:
66.84000

[ LogP ]:
2.28970

[ Index of Refraction ]:
1.474

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-tert-butoxycarbonyl-4,4-difluoro-3,3-dimethylproline methyl ester
  • 1-tert-Butyl 2-methyl 3,3-dimethyl-4-oxopyrrolidine-1,2-dicarboxylate

DownStream

Related Compounds

  • 1-(1-Ethylpyrazol-3-yl)-N-methylmethanamine;hydrochloride
  • (E)-5,5,5-Trifluoropent-3-en-2-amine;hydrochloride
  • 9-(Azetidin-3-yl)purin-6-amine;dihydrochloride
  • (1R,6S,7R)-7-(Trifluoromethyl)-2-oxa-5-azabicyclo[4.1.0]heptane;hydrochloride
  • 5-Benzyl-1,2-oxazol-4-amine;hydrochloride
  • 2-Benzyl-3,4,7,8,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-6-one;dihydrochloride
  • 3-[(2-Methylpropan-2-yl)oxy]azepane;hydrochloride
  • 3-(Dimethylamino)pyrrolidine-3-carboxamide;dihydrochloride
  • Tert-butyl (2R,4aS,7aS)-2-(aminomethyl)-3,4a,5,6,7,7a-hexahydro-2H-cyclopenta[b][1,4]oxazine-4-carboxylate;hydrochloride
  • 1-O-Tert-butyl 3-O-methyl 3-(aminomethyl)azetidine-1,3-dicarboxylate;hydrochloride
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