1,2-Dihydroxybenz[i]aceanthrylene

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Names

[ CAS No. ]:
479-23-2

[ Name ]:
1,2-Dihydroxybenz[i]aceanthrylene

[Synonym ]:
Benz[j]aceanthrylene, 1,2-dihydro-
EINECS 207-528-2
7,8-Dimethylen-benz<a>anthracen
1,2-Dihydroxybenz[i]aceanthrylene
1,2-Dihydrocyclopenta[ij]tetraphene
cholanthrene

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
495.0±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H14

[ Molecular Weight ]:
254.325

[ Flash Point ]:
245.3±14.5 °C

[ Exact Mass ]:
254.109543

[ LogP ]:
6.65

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.806

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FZ2625000
CHEMICAL NAME :
Cholanthrene
CAS REGISTRY NUMBER :
479-23-2
BEILSTEIN REFERENCE NO. :
1965625
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H14
MOLECULAR WEIGHT :
254.34
WISWESSER LINE NOTATION :
L E6 D6656 1A T&&&T&J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 mg/kg/7W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
REFERENCE :
PRLBA4 Proceedings of the Royal Society of London, Series B: Biological Sciences. (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK) V.76- 1905- Volume(issue)/page/year: 123,343,1937
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 1,695,1941
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 1,685,1941 *** REVIEWS *** TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Pc,4,1972

Synthetic Route

Precursor & DownStream

Precursor

  • 6-acetoxycholanthrene
  • 1,2,2a,3,4,5,6b,7,8,9,10,10a,11,12-tetradecahydro-benz[j]aceanthrylene
  • 1-Cholanthrenone
  • indan-4-yl-[1]naphthyl ketone
  • 2a,3,4,5,6b,7,8,9,10,10a,11,12-dodecahydro-2H-benz[j]aceanthrylen-1-one
  • 2-Oxo-2,3,4,5,6,7-hexahydro-cholanthren
  • 5-Oxo-2a,3,4,5-tetrahydro-cholanthren
  • β-[1,2-Cyclopenteno-phenanthryl-(3')]-propionsaeure
  • Hydrochloric acid
  • acetic acid

DownStream

  • 1,2,6,12b-tetrahydrobenzo[j]aceanthrylene

Related Compounds

  • Benzo[b]naphtho[1,2-i]phenazin-5(8H)-one,6-chloro-8-methyl-
  • [3-(3-Amino-phenyl)-imidazo 1,2-i ]pyridazin-6-yl]-(1-methyl-piperidin-4-yl)-amine
  • 16H-benzo[a]benzo[4',5']selenopheno[2',3':4,5]benzo[1,2-i]carbazole
  • 1,2-dihydrobenzo[j]aceanthrylene-1,2-diol
  • 1,2-Dihydrobenz[l]aceanthrylene
  • 1,2-dihydrobenzo[j]aceanthrylene-9,10-dione