1,2-Dihydroxybenz[i]aceanthrylene

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Names

[ CAS No. ]:
479-23-2

[ Name ]:
1,2-Dihydroxybenz[i]aceanthrylene

[Synonym ]:
Benz[j]aceanthrylene, 1,2-dihydro-
EINECS 207-528-2
7,8-Dimethylen-benz<a>anthracen
1,2-Dihydroxybenz[i]aceanthrylene
1,2-Dihydrocyclopenta[ij]tetraphene
cholanthrene

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
495.0±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₄

[ Molecular Weight ]:
254.325

[ Flash Point ]:
245.3±14.5 °C

[ Exact Mass ]:
254.109543

[ LogP ]:
6.65

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.806

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ2625000

CHEMICAL NAME :: Cholanthrene

CAS REGISTRY NUMBER :: 479-23-2

BEILSTEIN REFERENCE NO. :: 1965625

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C20-H14

MOLECULAR WEIGHT :: 254.34

WISWESSER LINE NOTATION :: L E6 D6656 1A T&&&T&J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg/7W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

REFERENCE :: PRLBA4 Proceedings of the Royal Society of London, Series B: Biological Sciences. (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK) V.76- 1905- Volume(issue)/page/year: 123,343,1937

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 1,695,1941

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 1,685,1941 *** REVIEWS *** TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Pc,4,1972

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

6-acetoxycholanthrene
1,2,2a,3,4,5,6b,7,8,9,10,10a,11,12-tetradecahydro-benz[j]aceanthrylene
1-Cholanthrenone
indan-4-yl-[1]naphthyl ketone
2a,3,4,5,6b,7,8,9,10,10a,11,12-dodecahydro-2H-benz[j]aceanthrylen-1-one
2-Oxo-2,3,4,5,6,7-hexahydro-cholanthren
5-Oxo-2a,3,4,5-tetrahydro-cholanthren
β-[1,2-Cyclopenteno-phenanthryl-(3')]-propionsaeure
Hydrochloric acid
acetic acid

DownStream

Related Compounds

Benzo[b]naphtho[1,2-i]phenazin-5(8H)-one,6-chloro-8-methyl-
[3-(3-Amino-phenyl)-imidazo 1,2-i ]pyridazin-6-yl]-(1-methyl-piperidin-4-yl)-amine
16H-benzo[a]benzo[4',5']selenopheno[2',3':4,5]benzo[1,2-i]carbazole
1,2-dihydrobenzo[j]aceanthrylene-1,2-diol
1,2-Dihydrobenz[l]aceanthrylene
1,2-dihydrobenzo[j]aceanthrylene-9,10-dione
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
[1-(3,5-dimethylphenyl)-1H-1,2,3-triazol-4-yl]methanamine
Methyl 2-(2-hydroxy-2-methylpropoxy)-5-(trifluoromethyl)benzoate
4,4,4-trifluoro-N-(2-hydroxy-2,3-dihydro-1H-inden-1-yl)butanamide
3-[(2-Fluorophenoxy)methyl]pyridine
4-[(3-Chloro-thiophen-2-yl)-hydroxy-methyl]-piperidine-1-carboxylic acid tert-butyl ester
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
N-(2,3-Dihydro-2-oxo-1H-indol-5-yl)-4-[(4-methoxyphenyl)methyl]-I+/--oxo-1-piperidineacetamide
Methyl 4-fluoro-3-(methylamino)benzoate