Chrysophanic acid

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Names

[ CAS No. ]:
481-74-3

[ Name ]:
Chrysophanic acid

[Synonym ]:
1,8-dihydroxy-3-methylanthracene-9,10-dione
Chrysophal
2-methyl-4,5-dihydroxy-9,10-anthraquinone
CHRYSOPHANOL
1,8-Dihydroxy-3-Methyl-Anthraquinone
turkeyrhubarb
1,8-Dihydroxy-3-methyl-9,10-anthraquinone
MFCD00001208
9,10-Anthracenedione, 1,8-dihydroxy-3-methyl-
1,8-Dihydroxy-3-methylanthra-9,10-quinone
2-Methyl-4,5-dihydroxyanthraquinone
Chrysophanic acid
C.I. Natural Yellow 23
EINECS 207-572-2
RHUBARB EXTRACT
3-methyl-1,8-dihydroxyanthraquinone
1,8-Dihydroxy-3-methylanthraquinone
1,8-dihydroxy-3-methyl-9,10-antraquinone

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
489.5±45.0 °C at 760 mmHg

[ Melting Point ]:
194-198 °C

[ Molecular Formula ]:
C₁₅H₁₀O₄

[ Molecular Weight ]:
254.238

[ Flash Point ]:
263.9±25.2 °C

[ Exact Mass ]:
254.057907

[ PSA ]:
74.60000

[ LogP ]:
5.03

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.710

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
<0.1 g/100 mL at 18 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB6725000

CHEMICAL NAME :: Anthraquinone, 1,8-dihydroxy-3-methyl-

CAS REGISTRY NUMBER :: 481-74-3

LAST UPDATED :: 199410

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H10-O4

MOLECULAR WEIGHT :: 254.25

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ F1 NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 500 ug/plate

REFERENCE :: BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/38:Irritating to eyes and skin . R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CB6725000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

8-Methyl Chrysophanol
Chrysophanol 8-O-glucoside
8-hydroxy-1-methoxy-3-methylanthracene-9,10-dione
3-(bromomethyl)-1,8-dihydroxy-9,10-Anthracenedione
1,8-DIMETHOXY-3-METHYLANTHRAQUINONE
(1R,4aS,9aR)-9a-chloro-8-hydroxy-1-methoxy-3-methyl-1-((trimethylsilyl)oxy)-1,4,4a,9a-tetrahydroanthracene-9,10-dione
1,4,4a,9a-Tetrahydro-1,8-dihydroxy-3-methyl-9,10-anthrachinon
2-bromo-8-hydroxynaphthalene-1,4-dione
Aloeemodin

DownStream

9,10-Anthracenedione,1,4,5-trihydroxy-2-methyl-
Rhein
Aloeemodin
(8-acetyloxy-3-methyl-9,10-dioxo-anthracen-1-yl) acetate
4-Hydroxyisophthalic acid
5-Hydroxyisophthalic acid
Oxalic acid
2-METHYLANTHRACENE
Chrysophanol 8-O-glucoside
8-Methyl Chrysophanol

Customs

[ HS Code ]: 2942000000

Articles

Chrysophanol affords neuroprotection against microglial activation and free radical-mediated oxidative damage in BV2 murine microglia.

Int. J. Clin. Exp. Med. 8 , 3447-55, (2015)

In this study, chrysophanol, isolated from a marine fungus, was examined for its protective effects against inflammatory responses and oxidative stress in BV2 microglia. Chrysophanol was studied to as...

Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.

Chin. J. Integr. Med. 18(9) , 708-13, (2012)

To investigate the effect of prescription compatibility on the pharmacokinetics of components from Dachengqi Decoction (DCQD, ) in rats.Twenty-four male rats were randomly and equally divided into the...

Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 88-93, (2015)

Most herbal medicines are prescribed in combination based on the theory of TCM to obtain synergistic effects or diminish the possible adverse reactions. Compatibility refers to the combination of two ...