RG108

Suppliers

Names

[ Name ]:
RG108

[Synonym ]:
DNA Methyltransferase Inhibitor
N-phthalimide l-tryptophane
1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-
N-Phthalyl-L-tryptophan
(2S)-2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
N-Phth-Trp-OH
RG108

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
606.0±50.0 °C at 760 mmHg

[ Melting Point ]:
192-194℃

[ Molecular Formula ]:
C₁₉H₁₄N₂O₄

[ Molecular Weight ]:
334.326

[ Flash Point ]:
320.3±30.1 °C

[ Exact Mass ]:
334.095367

[ PSA ]:
90.47000

[ LogP ]:
3.33

[ Appearance of Characters ]:
yellow

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.741

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
DMSO: >10mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors.

Oncotarget 6(7) , 5134-46, (2015)

Dual PI3K/mTOR(phosphatidylinositol 3-kinase/mammalian target of rapamycin) inhibitors are being evaluated clinically for the treatment of tumors with a hyperactivated PI3K/mTOR pathway. However, unex...

c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication.

Biochim. Biophys. Acta 1849 , 1319-28, (2015)

In metazoans, DNA replication is a highly regulated and ordered process that occurs during the S phase of cell cycle. It begins with the licensing of origins of replication usually found in close prox...

DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection.

Proteomics 15 , 1968-82, (2015)

Viral infections can alter the cellular epigenetic landscape, through modulation of either DNA methylation profiles or chromatin remodeling enzymes and histone modifications. These changes can act to ...