Dihydroberberine

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Names

[ CAS No. ]:
483-15-8

[ Name ]:
Dihydroberberine

[Synonym ]:
9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline
Dihydroberbine
6H-1,3-Benzodioxolo[5,6-a]benzo[g]quinolizine, 5,8-dihydro-9,10-dimethoxy-
9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline
Dihydroberberine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
557.8±50.0 °C at 760 mmHg

[ Melting Point ]:
223-224ºC (dec.)

[ Molecular Formula ]:
C20H19NO4

[ Molecular Weight ]:
337.369

[ Flash Point ]:
170.7±27.3 °C

[ Exact Mass ]:
337.131409

[ PSA ]:
40.16000

[ LogP ]:
5.09

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.679

[ Storage condition ]:
2-8C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DR9808500
CHEMICAL NAME :
Berbine, 13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)-
CAS REGISTRY NUMBER :
483-15-8
BEILSTEIN REFERENCE NO. :
0344128
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H19-N-O4
MOLECULAR WEIGHT :
337.40
WISWESSER LINE NOTATION :
T G6 E6 B665 EN SO UO FH TH&&T&&J HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
190 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,486,1981

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Berberine hydrochloride
  • 7,8-dimethoxy-2-(3,4-methylenedioxyphenethyl)-1,2,3,4-tetrahydroisoquinolin-3-one
  • Berberinol
  • Tetrahydroberberine
  • 2-(6-bromo-benzo[1,3]dioxol-5-yl)-ethylamine
  • 2-bromo-N-(2,3-dimethoxybenzyl)-4,5-methylenedioxyphenethylamine
  • 2-(2-bromo-4,5-methylenedioxyphenethyl)-7,8-dimethoxy-4-methylthio-1,2,3,4-tetrahydroisoquinolin-3-one
  • 2,3-Dimethoxybenzaldehyde
  • Berberine
  • Diethyl ether

DownStream

  • Berberine hydrochloride
  • berberinephenolbetaine
  • Berberinol
  • 1,3-Dioxolo[4,5-g]isoquinolin-5(6H)-one,7,8-dihydro-
  • O-methylpseudopianic acid
  • 3-[3,4-dihydro-1-oxo-6,7-(methylenedioxy)-2H-isoquinolin-2-yl]-4,5-dimethoxy-1(3H)-isobenzofuranone
  • Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-13-methyl-, chloride (1:1)

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Dihydroberberine
  • 8-hydroxydihydroberberine
  • 8-methoxydihydroberberine
  • 8-Trichloromethyldihydroberberine
  • 8-(Trichloromethyl)-7,8-dihydroberberine-13-carboxaldehyde
  • Benzenebutanenitrile, I(3)-amino-2-bromo-3-fluoro-5,6-dihydroxy-
  • 4-Nitro-2-(trifluoromethoxy)benzyl chloride
  • 5-Nitro-2-(trifluoromethoxy)benzyl chloride
  • 2,2-Difluoro-1-(2-methoxy-4-methylphenyl)ethan-1-ol
  • 5-Bromo-4-methyl-2-nitrobenzene-1-sulfonamide
  • 1-Bromo-1-(2-(trifluoromethyl)phenyl)propan-2-one
  • 2,4-Dichloro-6-(difluoromethyl)-5-fluoropyrimidine
  • 2-Benzoxazoleacetic acid, 7-(bromomethyl)-I+/--hydroxy-
  • 3-Isopropyl-2-nitrobenzaldehyde
  • (2R)-2-(2,4,5-trifluorophenyl)propanoic acid
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