fervenulin

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Names

[ CAS No. ]:
483-57-8

[ Name ]:
fervenulin

[Synonym ]:
6,8-Dimethyl-8H-pyrimido[5,4-e][1,2,4]triazin-5,7-dion
6.8-Dimethyl-5.7-dioxo-5.6.7.8-tetrahydro-pyrimido<5.4-e>-as-triazin
Fervenuline
6,8-dimethyl-8H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione
Kc 1017
Compound 7215
U-7118
Planomycin
Pulanomycin
Phervenulin

Chemical & Physical Properties

[ Density]:
1.474g/cm3

[ Boiling Point ]:
417.2ºC at 760 mmHg

[ Molecular Formula ]:
C₇H₇N₅O₂

[ Molecular Weight ]:
193.16300

[ Flash Point ]:
206.1ºC

[ Exact Mass ]:
193.06000

[ PSA ]:
82.67000

[ Vapour Pressure ]:
3.61E-07mmHg at 25°C

[ Index of Refraction ]:
1.601

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7900000

CHEMICAL NAME :: Pyrimido(5,4-e)-as-triazine-5,7(6H,8H)-dione, 6,8-dimethyl-

CAS REGISTRY NUMBER :: 483-57-8

LAST UPDATED :: 199603

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H7-N5-O2

MOLECULAR WEIGHT :: 193.19

WISWESSER LINE NOTATION :: T66 BVNVN GNN JNJ C1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,220,1959/1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,199,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,518,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 11200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,220,1959/1960

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3,6,8-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
acetic acid
3-(hydroxymethyl)-6,8-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione
3-(dibromomethyl)-6,8-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione
9-Aminotheophylline
6,8-dimethyl-4-oxidopyrimido[5,4-e][1,2,4]triazin-4-ium-5,7-dione

DownStream

1,3-dimethyl-8-morpholin-4-yl-7H-purine-2,6-dione
1,3-dimethyl-8-(1-piperidyl)-7H-purine-2,6-dione
2,4(1H,3H)-Pyrimidinedione,5-amino-1,3-dimethyl-
1,3-dimethylpyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione

Related Compounds

fervenulin-3-one
Fervenulin-4-oxide
2-Methyl-fervenulin
fervenulin-3-one-4-oxide
3-Ethylfervenulin-4-oxid
3-p-Nitrophenylfervenulin
2-[1-(4-Chloro-3-methoxyphenyl)cyclopropyl]ethan-1-amine
3-(3-Chloropyridin-4-yl)-2-hydroxy-3-methylbutanoic acid
(2S)-4-(5,6-dichloropyridin-3-yl)butan-2-amine
(2S)-1-(5,6-dichloropyridin-3-yl)propan-2-amine
5-Chloro-2-(piperidin-3-yloxy)phenol
2-(Dimethylamino)-N-[(phenylamino)carbonyl]propanamide
4-(2-Chloro-5-methylphenyl)but-3-en-2-amine
Methyl 2-(3-chloropyridin-4-yl)-2-hydroxyacetate
4-Chloro-1-methoxy-2-(2-methylbut-3-yn-2-yl)benzene
rac-(1R,3R)-3-(2-chloro-6-hydroxyphenyl)-2,2-dimethylcyclopropane-1-carboxylic acid

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