4-Methoxyindole

Names

[ CAS No. ]:
4837-90-5

[ Name ]:
4-Methoxyindole

[Synonym ]:
MFCD00009737
1H-Indole, 4-methoxy-
4-Methoxylindole
4-Methoxyindole
4-Methoxy-1H-indole

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
306.9±0.0 °C at 760 mmHg

[ Melting Point ]:
69-70 °C(lit.)

[ Molecular Formula ]:
C₉H₉NO

[ Molecular Weight ]:
147.17

[ Flash Point ]:
109.2±10.1 °C

[ Exact Mass ]:
147.068420

[ PSA ]:
25.02000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.637

[ Storage condition ]:
Keep Cold

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Methoxyindole-2-carboxylic acid
4-Hydroxyindole
methyl iodide
2-(2-methoxy-6-nitrophenyl)acetonitrile
3-methoxy-trans-2-[β-(dimethylamino)vinyl]-nitrobenzene
4-methoxy-1-[(4-methylphenyl)sulfonyl]indole
Triethanolamine
3-anisidine
2-methyl-3-nitroanisole

DownStream

4-Methoxy-1H-indole-3-carbaldehyde
(4-Methoxy-1H-indol-3-yl)acetonitrile
1-(2-hydroxyethyl)-2,3-dihydroindol-4-ol
5-methoxytryptoline
4-METHOXY-1-METHYL-1H-INDOLE
4-Methoxyindoline
1-(tert-Butoxycarbonyl)-4-methoxy-1H-indol-2-ylboronic acid
2-(4-Methoxy-1H-indol-3-yl)ethanamine
4-METHOXY-1-METHYL-1H-INDOLE-3-CARBALDEHYDE
[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indol-1-yl]-tri(propan-2-yl)silane

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pharmacokinetics and pharmacodynamics of 3,3'-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes.

J. Pharmacokinet. Pharmacodyn. 42 , 401-8, (2015)

3,3'-Diindolylmethane (DIM) has been investigated as a potential anti-cancer chemopreventive agent in many preclinical and clinical studies. In this study, we sought to characterize the pharmacokineti...

Intranasal delivery of liposomal indole-3-carbinol improves its pulmonary bioavailability.

Int. J. Pharm. 477(1-2) , 96-101, (2014)

Indole-3-carbinol (I3C), a constituent of commonly consumed Brassica vegetables, has been shown to have anticancer effects in a variety of preclinical models of lung cancer. However, it has shown only...

HPLC and solubility study of the interaction between pindolol and cyclodextrins.

J. Pharm. Biomed. Anal. 37(3) , 487-92, (2005)

The complexation with beta-cyclodextrin (beta-CD) has been investigated using reversed-phase liquid chromatography. The compounds tested have been pindolol and, for comparison purposes, indole and 4-m...