dihydralazine

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Names

[ CAS No. ]:
484-23-1

[ Name ]:
dihydralazine

[Synonym ]:
1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone
Dihydralazin
Nepresol
1,4-dihydrazinophthanazine
1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone, (1Z,4Z)-
1,4-Dihydrazinophthalazine
Nepresolin
Dihydrallazine
Dihydrallazin
4-Hydrazino-1-hydrazono-1,2-dihydrophthalazine
phthalazine, 1,4-bis(hydrazino)-
Phthalazine, 1,4-bis(hydrazinyl)-
1,4-dihydrazinophtalazine
(1Z,4E)-1,4-Dihydrazono-1,2,3,4-tetrahydrophthalazine
Nepressol
Hypopresol
1,4-bis(hydrazino)phthalazine
1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone, (1Z,4E)-
(1Z,4Z)-1,4-Dihydrazono-1,2,3,4-tetrahydrophthalazine
Ophthazin
dihydralazine
1,4-dihydrazinylphthalazine

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
419.9±28.0 °C at 760 mmHg

[ Melting Point ]:
180ºC

[ Molecular Formula ]:
C₈H₁₀N₆

[ Molecular Weight ]:
190.205

[ Flash Point ]:
207.7±24.0 °C

[ Exact Mass ]:
190.096695

[ PSA ]:
108.34000

[ LogP ]:
0.73

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.810

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH8849900

CHEMICAL NAME :: Phthalazine, 1,4-dihydrazino-

CAS REGISTRY NUMBER :: 484-23-1

BEILSTEIN REFERENCE NO. :: 0183442

LAST UPDATED :: 199703

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H10-N6

MOLECULAR WEIGHT :: 190.24

WISWESSER LINE NOTATION :: T66 CNNJ BMZ EMZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 106 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 250 ug/kg

SEX/DURATION :: female 32 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 125 ug/tube

REFERENCE :: ABPLAF Acta Biochimica Polonica. (Polish Biochemical Society, Posteura 3, 01-093 Warsaw, Poland) V.1- 1954- Volume(issue)/page/year: 42,291,1995

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Phthalonitrile
1,4-Dichlorophthalazine
1-chloro-4-methoxyphthalazine
1-ETHOXY-4-CHLOROPHTHALAZINE
1-Chloro-4-hydrazinophthalazine
Phthalimide diimide
1,4-Dimercapto phthalazine
2,3-Dihydrophthalazine-1,4-dione
Phthalic acid

DownStream

N,N-bis[(2-chlorophenyl)methylideneamino]phthalazine-1,4-diamine
Benzaldehyde, 2,6-dichloro-, 1,4-phthalazinediyldihydrazone(8CI,9CI)
2-Propenal, 3-phenyl-,1,4-phthalazinediyldihydrazone (9CI)
Benzaldehyde, 3-nitro-,1,4-phthalazinediyldihydrazone (9CI)
Benzaldehyde,4-chloro-, 1,4-phthalazinediyldihydrazone (9CI)
Benzaldehyde, p-nitro-,1,4-phthalazinediyldihydrazone (8CI)
5-Nitrophthalazine
5-Aminophthalazine
Phthalazine
Benzaldehyde,2-methoxy-, 1,4-phthalazinediyldihydrazone (9CI)

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%