Ethyl 6-methyl-2-phenyl-4-quinolinecarboxylate

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Names

[ CAS No. ]:
485-34-7

[ Name ]:
Ethyl 6-methyl-2-phenyl-4-quinolinecarboxylate

[Synonym ]:
Neocinchophen
Neophan
Tolysin
6-methyl-2-phenyl-quinoline-4-carboxylic acid ethyl ester
Neoatophan
Neoquinophan
6-Methyl-2-phenyl-chinolin-4-carbonsaeure-aethylester
Neocincophen
Novo-rheumatophin
Novatophan
Neomagnephen
Neu-nylofanol

Chemical & Physical Properties

[ Density]:
1.152g/cm3

[ Boiling Point ]:
455.7ºC at 760 mmHg

[ Molecular Formula ]:
C19H17NO2

[ Molecular Weight ]:
291.34400

[ Flash Point ]:
229.4ºC

[ Exact Mass ]:
291.12600

[ PSA ]:
39.19000

[ LogP ]:
4.38690

[ Vapour Pressure ]:
1.72E-08mmHg at 25°C

[ Index of Refraction ]:
1.613

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VB2251850
CHEMICAL NAME :
4-Quinolinecarboxylic acid, 6-methyl-2-phenyl-, ethyl ester
CAS REGISTRY NUMBER :
485-34-7
BEILSTEIN REFERENCE NO. :
0251071
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H17-N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 gm/kg/7D-I
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 48,341,1933
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
21600 mg/kg/7W-I
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 48,341,1933

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethanol
  • 6-methyl-2-phenyl-quinoline-4-carbonyl chloride
  • Acetophenone
  • Bromoethane
  • monochloroethane
  • Sulfuric acid
  • 6-METHYL-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID
  • Hydrochloric acid

DownStream

  • 6-methyl-2-phenylquinoline-4-carbohydrazide

Related Compounds

  • 1-methyl-2-oxo-2-phenylethyl 6-methyl-2-phenyl-4-quinolinecarboxylate
  • 1-methyl-2-(4-methylphenyl)-2-oxoethyl 6-methyl-2-phenyl-4-quinolinecarboxylate
  • 3-Ethyl-6-methyl-2-phenyl-4(3H)-pyrimidinone
  • Ethyl ({6-[(methylsulfanyl)methyl]-2-phenyl-4-pyrimidinyl}sulfanyl)acetate
  • 1-(6-methyl-2-phenyl-4-sulfanylidene-1H-pyrimidin-5-yl)ethanone
  • Methyl 6-chloro-3-methyl-2-phenyl-4-quinolinecarboxylate
  • (2-Fluoro-3,6-dimethoxyphenyl)(methyl)sulfane
  • 1-Chloro-1-(3-mercaptophenyl)propan-2-one
  • (1R,2R)-1-Amino-1-(2,3-dichlorophenyl)propan-2-OL
  • 1,3-Dimethyl-2-ethoxy-4-fluorobenzene
  • 1-Bromo-1-(4-fluoro-3-(methylthio)phenyl)propan-2-one
  • 1-(2-(Bromomethyl)-6-hydroxyphenyl)-2-chloropropan-1-one
  • 1,3-Difluoro-2-difluoromethoxy-4-ethylbenzene
  • 2-Fluoro-4-methyl-5-(trifluoromethoxy)aniline
  • 3-Chloro-N-[4-(difluoromethyl)phenyl]propanamide
  • 3-(1H-Imidazol-5-yl)-2,5-dimethylpiperazine
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