Cinchonidine
Suppliers
Names
[ CAS No. ]:
485-71-2
[ Name ]:
Cinchonidine
[Synonym ]:
(+)-cinchonine
(R)-4-Quinolinyl[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol
L-CINCHONIDINE
Cinchonan-9-ol, (8α,9R)-
(R)-4-Chinolinyl[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol
(-)-CINCHONIDINE
(R)-[(2S,4S,5R)-5-éthènyl-1-azabicyclo[2.2.2]oct-2-yl](4-quinoléinyl)méthanol
α-Quinidine
Cinchondine
Cinchovatine
MFCD00006783
Cinchonidine
1-Cinchonidine
EINECS 207-622-3
chinchonidine
a-quinidine
(8α,9R)-Cinchonan-9-ol
(8a,9R)-Cinchonan-9-ol
Cinchovatine (VAN)
TCMDC-123934
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
464.5±30.0 °C at 760 mmHg
[ Melting Point ]:
204-206ºC
[ Molecular Formula ]:
C19H22N2O
[ Molecular Weight ]:
294.391
[ Flash Point ]:
234.7±24.6 °C
[ Exact Mass ]:
294.173218
[ PSA ]:
36.36000
[ LogP ]:
3.35
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.652
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GD2975000
- CHEMICAL NAME :
- Cinchonidine
- CAS REGISTRY NUMBER :
- 485-71-2
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C19-H22-N2-O
- MOLECULAR WEIGHT :
- 294.43
- WISWESSER LINE NOTATION :
- T66 BNJ EYQ- DT66 A B CNTJ A1U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 206 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 4,265,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- >316 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H317-H361d-H373
[ Precautionary Statements ]:
P280
[ Target Organs ]:
Heart, Immune system
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S36/37
[ RIDADR ]:
UN 1544
[ WGK Germany ]:
3
[ RTECS ]:
GD2975000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2939200000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2939200000
Articles
Nature 465 , 305-10, (2010)
Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 19...
Org. Lett. 16(3) , 864-7, (2014)
A one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of cop...
Chimia 65(3) , 182-6, (2011)
Molecularly imprinted polymer microspheres were immobilized within a polymer nanofiber membrane by electrospinning. Such membranes simplify the handling of functional microspheres and provide specific...