Cinchonidine

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Names

[ CAS No. ]:
485-71-2

[ Name ]:
Cinchonidine

[Synonym ]:
(+)-cinchonine
(R)-4-Quinolinyl[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol
L-CINCHONIDINE
Cinchonan-9-ol, (8α,9R)-
(R)-4-Chinolinyl[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol
(-)-CINCHONIDINE
(R)-[(2S,4S,5R)-5-éthènyl-1-azabicyclo[2.2.2]oct-2-yl](4-quinoléinyl)méthanol
α-Quinidine
Cinchondine
Cinchovatine
MFCD00006783
Cinchonidine
1-Cinchonidine
EINECS 207-622-3
chinchonidine
a-quinidine
(8α,9R)-Cinchonan-9-ol
(8a,9R)-Cinchonan-9-ol
Cinchovatine (VAN)
TCMDC-123934

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
464.5±30.0 °C at 760 mmHg

[ Melting Point ]:
204-206ºC

[ Molecular Formula ]:
C₁₉H₂₂N₂O

[ Molecular Weight ]:
294.391

[ Flash Point ]:
234.7±24.6 °C

[ Exact Mass ]:
294.173218

[ PSA ]:
36.36000

[ LogP ]:
3.35

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.652

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD2975000

CHEMICAL NAME :: Cinchonidine

CAS REGISTRY NUMBER :: 485-71-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H22-N2-O

MOLECULAR WEIGHT :: 294.43

WISWESSER LINE NOTATION :: T66 BNJ EYQ- DT66 A B CNTJ A1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 206 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 4,265,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H317-H361d-H373

[ Precautionary Statements ]:
P280

[ Target Organs ]:
Heart, Immune system

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36/37

[ RIDADR ]:
UN 1544

[ WGK Germany ]:
3

[ RTECS ]:
GD2975000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2939200000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Cinchomeronic acid
(S)-(+)-2-METHYLGLUTARICACID
(r)-(-)-2-phenylbutyric acid
leucoline
(8S,9R)-(-)-N-Benzylcinchonidinium chloride
4(1H)-Quinolinone
D-(-)-Pantolactone
(3ξ,8α,9S)-1-Ethyl-9-hydroxycinchonan-1-ium iodide
(R)-3-Phenylbutyric acid
Formic Acid

Customs

[ HS Code ]: 2939200000

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