4-Quinolinecarboxylicacid, 3-hydroxy-2-phenyl-

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Names

[ CAS No. ]:
485-89-2

[ Name ]:
4-Quinolinecarboxylicacid, 3-hydroxy-2-phenyl-

[Synonym ]:
Hydroxycinchophene
3-hydroxy-2-phenyl-4-quinoline carboxylic acid
Reumartril
3-hydroxy-2-phenylquinoline-4-carboxylic cid
Oxinofen
Sintofene
Magnophenyl
2-Phenyl-3-hydroxy-chinchoninsaeure
oxicinchophen
3-hydroxy-2-phenyl-quinoline-4-carboxylic acid
Oxycinchophen
3-Hydroxy-2-phenylchinchoninsaeure
Chinoxone
Fenidrone
Magnofenyl

Chemical & Physical Properties

[ Density]:
1.374g/cm3

[ Boiling Point ]:
457.7ºC at 760mmHg

[ Melting Point ]:
206.5°C (rough estimate)

[ Molecular Formula ]:
C16H11NO3

[ Molecular Weight ]:
265.26300

[ Flash Point ]:
230.6ºC

[ Exact Mass ]:
265.07400

[ PSA ]:
70.42000

[ LogP ]:
3.30560

[ Vapour Pressure ]:
3.58E-09mmHg at 25°C

[ Index of Refraction ]:
1.712

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD3900000
CHEMICAL NAME :
Cinchoninic acid, 3-hydroxy-2-phenyl-
CAS REGISTRY NUMBER :
485-89-2
BEILSTEIN REFERENCE NO. :
0224526
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C16-H11-N-O3
MOLECULAR WEIGHT :
265.28
WISWESSER LINE NOTATION :
T66 BNJ CR& DQ EVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
495 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,79,1951
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JHHBAI Bulletin of the Johns Hopkins Hospital. (Baltimore, MD) V.1-119, 1889-1966. For publisher information, see JHMJAX. Volume(issue)/page/year: 86,89,1950
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
144 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,79,1951

Safety Information

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-phenyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-quinoline-4-carboxylic acid ethyl ester
  • ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-phenylquinoline-4-carboxylate
  • Phenacyl acetate
  • isatin
  • 3-methoxy-2-phenylquinoline-4-carboxylic acid
  • PhCH2COO(-)
  • 2-METHOXYACETOPHENONE
  • 2-Chloroacetophenone
  • 3-amino-2-phenylquinoline-4-carboxylic acid
  • 2-Bromoacetophenone

DownStream

  • 1,3-Dicyclohexylurea
  • Talnetant
  • 2-phenylquinolin-3-ol

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 4-(3-HYDROXY-2-PHENYL-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 3-hydroxy-2,6,8-trimethylquinoline-4-carboxylic acid
  • 3-hydroxy-2,6-dimethylquinoline-4-carboxylic acid
  • 4-Quinolinecarboxylicacid, 3-methyl-2-phenyl-, methyl ester
  • 4-Quinolinecarboxylicacid, 3-methyl-2-phenyl-, ethyl ester
  • 4-Imidazolidinone,3-hydroxy-2-phenyl-
  • (4-Isopropylbenzyl)(4-isopropylphenyl)amine
  • 3-(1-phenyl-1H-pyrazol-4-yl)-1,2-oxazole-5-carboxylic acid
  • 3-Benzyl-5-methylpyridin-2(1H)-one
  • 5,6-Diamino-3-(tetrahydro-3-furanyl)-2,4(1h,3h)-pyrimidinedione
  • 1-(5-ethyl-4-methyl-4H-1,2,4-triazol-3-yl)piperazine
  • Ethyl 3-hydrazinylpropanoate
  • 5,6-Diamino-1-(2-methoxyethyl)-1,3-dihydropyrimidine-2,4-dione
  • 6-Amino-1-(tetrahydro-3-furanyl)-2,4(1h,3h)-pyrimidinedione
  • 6-chloro-N-(2-chloro-4,6-dimethylphenyl)pyridine-3-carboxamide
  • Rel-(1R,3S)-3-aminocyclohexane-1-carbonitrile
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