triprolidine

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Names

[ CAS No. ]:
486-12-4

[ Name ]:
triprolidine

[Synonym ]:
MFCD00038040
(e)-pyridin
Triprolidin
(E)-2-[3-(1-Pyrrolidinyl)-1-p-toluenepropenyl]pyridine
(E)-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene
trans-2-[3-(1-Pyrrolidinyl)-1-p-tolypropenyl]pyridine
trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene
trans-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine
EINECS 207-627-0
Triprolidine
Tripyrolidine
1t-[2]Pyridyl-3-pyrrolidino-1c-p-tolyl-propen
(E)-1-(2-pyridyl)-3-pyrrolidin-1-yl-1-p-tolylpropene
1t-[2]pyridyl-3-pyrrolidino-1c-p-tolyl-propene
(E)-2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine

Chemical & Physical Properties

[ Density]:
1.061 g/cm3

[ Boiling Point ]:
435.4ºC at 760 mmHg

[ Melting Point ]:
126-130°C

[ Molecular Formula ]:
C19H22N2

[ Molecular Weight ]:
278.39100

[ Flash Point ]:
217.1ºC

[ Exact Mass ]:
278.17800

[ PSA ]:
16.13000

[ LogP ]:
3.85540

[ Vapour Pressure ]:
6.16E-09mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT5812000
CHEMICAL NAME :
Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)- , (E)-
CAS REGISTRY NUMBER :
486-12-4
LAST UPDATED :
199801
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H22-N2
MOLECULAR WEIGHT :
278.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
143 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - alteration of operant conditioning Behavioral - changes in psychophysiological tests
REFERENCE :
EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970- Volume(issue)/page/year: 47,331,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2700 mg/kg/90D-C
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands Liver - fatty liver degeneration
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,96,1985

Safety Information

[ Safety Phrases ]:
S36/37

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • alpha-[2-(1-pyrrolidinyl)ethyl]-alpha-(p-tolyl)pyridine-2-methanol

DownStream

  • Triprolidine hydrochloride

Related Compounds

  • z-triprolidine
  • Triprolidine HCl
  • Triprolidine HCl
  • Triprolidine hydrochloride
  • trans-Triprolidine hydrochloride
  • (E/Z)-Triprolidine-d8 hydrochloride
  • 2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hex-5-enamido]methyl}-1,3-thiazole-5-carboxylic acid
  • 2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]methyl}-1,3-thiazole-5-carboxylic acid
  • 2-{[2-cyclobutyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido]methyl}-1,3-thiazole-5-carboxylic acid
  • 2-{[3-(dimethylamino)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]methyl}-1,3-thiazole-5-carboxylic acid
  • 5-[N-ethyl-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)but-2-ynamido]pentanoic acid
  • 3-{[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopropyl]formamido}-4,4-difluorobutanoic acid
  • 7-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoyl]-7-azabicyclo[2.2.1]heptane-1-carboxylic acid
  • 7-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoyl]-7-azabicyclo[2.2.1]heptane-1-carboxylic acid
  • 4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-{[1-(1,3-thiazol-5-yl)ethyl]carbamoyl}butanoic acid
  • 2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanamido]methyl}-3,3,3-trifluoropropanoic acid
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