9-Fluorenone

Names

[ CAS No. ]:
486-25-9

[ Name ]:
9-Fluorenone

[Synonym ]:
9-Fluorenone
Diphenylene ketone
MFCD00001141
9H-Fluoren-9-one
EINECS 207-630-7
fluoren-9-one
Fluorenone
9-Oxofluorene

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
341.5±0.0 °C at 760 mmHg

[ Melting Point ]:
80-83 °C(lit.)

[ Molecular Formula ]:
C₁₃H₈O

[ Molecular Weight ]:
180.20

[ Flash Point ]:
144.1±13.7 °C

[ Exact Mass ]:
180.057510

[ PSA ]:
17.07000

[ LogP ]:
3.58

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.667

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
insoluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LL8925000

CHEMICAL NAME :: 9H-Fluoren-9-one

CAS REGISTRY NUMBER :: 486-25-9

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C13-H8-O

MOLECULAR WEIGHT :: 180.21

WISWESSER LINE NOTATION :: L B656 HVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 23,325,1989 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 7,453,1947 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - Z0225 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LL8925000

[ Packaging Group ]:
II; III

[ Hazard Class ]:
4.1

[ HS Code ]:
2914399090

Precursor & DownStream

Precursor

DownStream

9-[ethoxy(phenyl)phosphoryl]-N-pentylfluoren-9-amine
9-fluorenol
9-(9-hydroxyfluoren-9-yl)fluoren-9-ol
9-(9,10-dihydroanthracen-9-yl)fluoren-9-ol
9-cyclopropa[b]naphthalen-1-ylidenefluorene
2,3-Methanonaphthalene
9-methylfluorene-9-carbonyl chloride
Flurecol
9H-Fluorene-9-carboxylic acid
9H FLUORENE

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Rational design of indoleamine 2,3-dioxygenase inhibitors.

J. Med. Chem. 53 , 1172-89, (2010)

Indoleamine 2,3-dioxygenase (IDO) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. We have used the evolutionary docking algorit...

Photosensitizing properties of compounds related to benzophenone.

Acta Derm. Venereol. 93(1) , 30-2, (2013)

Benzophenone is a phototoxic compound with absorption maxima in the ultraviolet A (UVA) and ultraviolet B (UVB) range. Many benzophenone derivatives are known to be photosensitizing. On the other hand...

Broad spectrum analysis of polar and apolar organic compounds in submicron atmospheric particles.

J. Chromatogr. A. 1404 , 28-38, (2015)

A method for the quantitative analysis of organic compounds on submicron particulate matter (PM1) collected on quartz filters was developed. The compounds analyzed encompassed C22-C35 alkanes, polycyc...