Daidzein

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Names

[ CAS No. ]:
486-66-8

[ Name ]:
Daidzein

[Synonym ]:
4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-
k251b
K 251-6
MFCD00016954
Tatoin
Soybean Extract
7-Hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one (7-Hydroxy-3-(4-hydroxyphenyl)chromone
4',7-Dihydroxyisoflavone
Daidzeol
7-Hydroxy-3-(4-hydroxy phenyl) chromone
EINECS 207-635-4
7,4'-dihydroxyisoflavone
isoaurostatin
Daizeol
Daidzein
Daidsein

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
512.8±50.0 °C at 760 mmHg

[ Melting Point ]:
315-323°C (dec.)

[ Molecular Formula ]:
C₁₅H₁₀O₄

[ Molecular Weight ]:
254.238

[ Flash Point ]:
201.2±23.6 °C

[ Exact Mass ]:
254.057907

[ PSA ]:
70.67000

[ LogP ]:
2.78

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.699

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100040

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-

CAS REGISTRY NUMBER :: 486-66-8

BEILSTEIN REFERENCE NO. :: 0231523

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H10-O4

MOLECULAR WEIGHT :: 254.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,51,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P337 + P313

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S24-S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DJ3100040

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Formononetin
2-Bromo-4'-hydroxyacetophenone
b-Resorcylaldehyde
7-Benzyldaidzein
2,4-DIHYDROXYPHENYL P-HYDROXYBENZYL KETONE
Triethyl orthoformate
N,N-Dimethylformamide
Daidzin
4-Hydroxyphenylacetic acid

DownStream

6,7,4'-Trihydroxyisoflavone
Glycitein
3',4',7-trihydroxy isoflavone
Formononetin
Daidzein dimethyl ether
isoformononetin
O-Desmethylangolensin
Daidzein-d6
Daidzin
[4-(7-hydroxy-4-oxochromen-3-yl)phenyl] hexanoate

Articles

Comparing morphological, chemical and anti-diabetic characteristics of Puerariae Lobatae Radix and Puerariae Thomsonii Radix.

J. Ethnopharmacol. 164 , 53-63, (2015)

Puerariae Lobatae Radix (PLR) and Puerariae Thomsonii Radix (PTR) are traditional Chinese medicines used for the treatment of diabetes and cardiovascular diseases. These two herbs are used interchange...

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

Fitoterapia 98 , 11-21, (2014)

The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivativ...

A novel UHPLC method for the rapid and simultaneous determination of daidzein, genistein and equol in human urine.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1005 , 1-8, (2015)

This work reports on a novel method involving reverse-phased ultra-high performance liquid chromatography (UHPLC) plus a spectrophotometric photodiode array/fluorescence (FLR) detection system for det...