NSC 21723

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Names

[ CAS No. ]:
486-70-4

[ Name ]:
NSC 21723

[Synonym ]:
LUPININE
EINECS 207-638-0
MFCD00213431
(-)-LUPININE
OCTAHYDRO-1H-QUINOLIZIN-1-METHANOL
((1R,9aR)-Octahydro-1H-quinolizin-1-yl)methanol
LUPININ

Chemical & Physical Properties

[ Density]:
1.04 g/cm3

[ Boiling Point ]:
160-164°C 4mm

[ Melting Point ]:
62-65°C

[ Molecular Formula ]:
C10H19NO

[ Molecular Weight ]:
169.26

[ Flash Point ]:
160-164°C/4mm

[ Exact Mass ]:
169.14700

[ PSA ]:
23.47000

[ LogP ]:
1.18110

[ Vapour Pressure ]:
0.000928mmHg at 25°C

[ Index of Refraction ]:
1.525

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OK5802000
CHEMICAL NAME :
Lupinine
CAS REGISTRY NUMBER :
486-70-4
BEILSTEIN REFERENCE NO. :
0080447
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H19-N-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAGRAC Journal of Agricultural Research (Washington, DC). (Washington, DC) V.1-78, 1913-49. Discontinued. Volume(issue)/page/year: 32,51,1926

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S36/37

[ RIDADR ]:
1544

[ RTECS ]:
OK5802000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Related Compounds

  • NSC 319726
  • NSC 668036
  • NSC 80467
  • NSC 87877
  • NSC 15364
  • NSC 131114
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 4-ethyl-2-(4H-1,2,4-triazol-3-yl)-1,3-thiazole-5-carboxylate
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 5-(ethylsulfamoyl)-2-methylbenzoate
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-(2-cyanobenzenesulfonamido)acetate
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetate
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoate
  • 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl) 1-(9H-fluoren-9-yl)methyl 5-oxopiperazine-1,2-dicarboxylate
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-[(benzyloxy)methyl]-2-ethylbutanoate
  • 1-tert-butyl 3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl) 3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyrrolidine-1,3-dicarboxylate
  • tert-butyl 3-(4-{[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]carbonyl}-1-methyl-1H-pyrazol-3-yl)piperidine-1-carboxylate
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