Benzamide,N-acetyl-2-hydroxy-

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Names

[ CAS No. ]:
487-48-9

[ Name ]:
Benzamide,N-acetyl-2-hydroxy-

[Synonym ]:
Ethrisin
N-Salicoyl-acetamid
Actylamide
Arthrisin
N-Acetyl-salicylamid
salacetamide
Salicyl
L-749
Nacemide
Rixamone
Labazyl
Acetyl-salicyloyl-amin
acetyl-salicyloyl-amine

Chemical & Physical Properties

[ Density]:
1.263g/cm3

[ Boiling Point ]:
375.4ºC at 760mmHg

[ Melting Point ]:
148°

[ Molecular Formula ]:
C9H9NO3

[ Molecular Weight ]:
179.17300

[ Flash Point ]:
180.9ºC

[ Exact Mass ]:
179.05800

[ PSA ]:
66.40000

[ LogP ]:
1.05940

[ Vapour Pressure ]:
3.6E-06mmHg at 25°C

[ Index of Refraction ]:
1.568

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VN6650000
CHEMICAL NAME :
Salicylamide, N-acetyl-
CAS REGISTRY NUMBER :
487-48-9
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H9-N-O3
MOLECULAR WEIGHT :
179.19
WISWESSER LINE NOTATION :
QR BVMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,205,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2440378

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-(aminocarbonyl)phenyl acetate
  • Acetylsalicyloyl chloride
  • Chloro(chlorosulfanyl)oxomethane
  • 2-methyl-1,3-benzoxazin-4-one,perchloric acid
  • 2-methyl-1,3-benzoxazin-4-one
  • Ethanoic anhydride
  • Salicylamide
  • Acetyl chloride
  • Triethyl orthoacetate
  • 4H-1,3-BENZOXAZIN-4-ONE, 2,3-DIHYDRO-2-METHYL-

DownStream

  • 6-(5-methyl-2-phenyl-1H-1,2,4-triazol-3-ylidene)cyclohexa-2,4-dien-1-one
  • 2-(3-METHYL-1,2,4-OXADIAZOL-5-YL)PHENOL

Related Compounds

  • Benzamide, N-(2-hydroxy-1,1-dimethylethyl)-2-methyl
  • Benzamide, N-(2-hydroxy-5-methylphenyl)-3-methoxy- (9CI)
  • Benzamide, N-(2-hydroxy-2-methylpropyl)-3-nitro-
  • Benzamide, N-(2-hydroxy-1-methylethyl)-
  • Benzamide,N-(2-hydroxy-1,2-diphenylethyl)-p-nitro-, erythro- (8CI)
  • Benzamide,N-(2-hydroxy-2-methylpropyl)-4-nitro-
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 2-methyl-6-[(2R)-oxiran-2-yl]quinoline
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide