Butein

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Names

[ CAS No. ]:
487-52-5

[ Name ]:
Butein

[Synonym ]:
Chalcone, 2',3,4,4'-tetrahydroxy- (7CI,8CI)
MFCD00017300
(E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
(2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one
(2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
Einecs 207-659-5
2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-, (2E)-
Butein,2',3,4,4'-Tetrahydroxychalcone
Butein
2',3,4,4'-TETRAHYDROCHALCONE
3,4,2',4'-TETRAHYDROXYCHALCONE
QR CQ DV1U1R CQ DQ &&E Form
2',3,4,4'-TETRAHYDROXYCHALCONE
(E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one
2′,3,4,4′-Tetrahydroxychalcone

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
560.9±50.0 °C at 760 mmHg

[ Melting Point ]:
216°C

[ Molecular Formula ]:
C15H12O5

[ Molecular Weight ]:
272.25

[ Flash Point ]:
307.1±26.6 °C

[ PSA ]:
17.07000

[ LogP ]:
2.66

[ Appearance of Characters ]:
solid | yellow

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.748

[ Storage condition ]:
-20°C

[ Water Solubility ]:
DMSO: >50 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

  • butin
  • 2,4-Dihydroxyacetophenone
  • 3,4-Dihydroxybenzaldehyde
  • 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-benzaldehyde
  • 2',4'-bis(tetrahydropyran-2-yloxy)acetophenone
  • 1-(2,4-bis(methoxymethoxy)phenyl)ethanone
  • 3,4-bis(methoxymethoxy)benzaldehyde
  • Benzaldehyde
  • 1-(2,4-dimethoxyphenyl)prop-2-en-1-one

DownStream

  • 3',4',7-trihydroxy isoflavone
  • But-2-yne
  • 2,4-Dihydroxyacetophenone
  • protocatechuic acid
  • Resorcine
  • 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)propan-1-one

Articles

Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a.

Int. J. Mol. Med. 36 , 957-66, (2015)

Drug resistance remains a major challenge in cancer therapy. Butein, a polyphenolic compound, has been shown to exhibit anticancer activity through the inhibition of the activation of the protein kina...

Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth.

Mol. Carcinog. 54(4) , 322-31, (2015)

Lung cancer is a leading cause of death worldwide and MET amplification is a major therapeutic limitation in acquired-resistance lung cancer. We hypothesized that butein, a phytochemical, can overcome...

Butein induces apoptosis in human uveal melanoma cells through mitochondrial apoptosis pathway.

Curr. Eye Res. 37 , 730-739, (2012)

To study the cytotoxic effects and related signaling pathways of butein on human uveal melanoma cells in vitro.Three human uveal melanoma cell lines (M17, SP6.5, and C918), retinal pigment epithelial ...


More Articles

Related Compounds

  • butein
  • Butein 4'-glucoside
  • Butein-3-β-D-glucoside, Monospermoside
  • (4-Butoxyphenyl)(pyridin-3-yl)methanone
  • 2-(4-fluorophenoxy)-N-[1-(2-furylmethyl)-1H-pyrazol-5-yl]butanamide
  • (3,5-Dichlorophenyl)(pyridin-3-yl)methanone
  • 3-(2,4-Dimethoxybenzoyl)pyridine
  • 2-chloro-N-cyclohexylpyridine-3-sulfonamide
  • (2,6-Dimethylphenyl)(pyridin-3-yl)methanone
  • 3-(3,5-Dimethylbenzoyl)pyridine
  • 3-(3,4,5-Trifluorobenzoyl)pyridine
  • 3-(Pentafluorobenzoyl)pyridine
  • 5-(4-Bromobenzoyl)pyrimidine
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