AR-A014418

Suppliers

Names

[ Name ]:
AR-A014418

[Synonym ]:
1-(4-Methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea
1q5k
GSK-3beta Inhibitor VIII
Urea, N-[(4-methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)-
Kinome_1268
N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea
AR-A014418
GSK-3β Inhibitor VIII
1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Melting Point ]:
208-210?C (dec.)

[ Molecular Formula ]:
C₁₂H₁₂N₄O₄S

[ Molecular Weight ]:
308.313

[ Exact Mass ]:
308.057922

[ PSA ]:
137.31000

[ LogP ]:
1.43

[ Appearance of Characters ]:
off-white to tan

[ Index of Refraction ]:
1.666

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: ≥20mg/mL, clear, light yellow

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-37/38-41

[ Safety Phrases ]:
26-36/39

[ RIDADR ]:
NONH for all modes of transport

Articles

Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease.

Neurobiol. Aging 36(1) , 211-27, (2014)

It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which i...

Thr175-phosphorylated tau induces pathologic fibril formation via GSK3β-mediated phosphorylation of Thr231 in vitro.

Neurobiol. Aging 36 , 1590-9, (2015)

We have previously shown that amyotrophic lateral sclerosis with cognitive impairment can be characterized by pathologic inclusions of microtubule-associated protein tau (tau) phosphorylated at Thr(17...

Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3β.

APMIS 123 , 373-82, (2015)

The transcription factor signal transducers and activators of transcription 3 (STAT3) can promote cancer metastasis, but its underlying regulatory mechanisms in gastric cancer cell invasiveness still ...

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