Hydroxytetracaine

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Names

[ CAS No. ]:
490-98-2

[ Name ]:
Hydroxytetracaine

[Synonym ]:
Salicacaine
Oxypentocain
Salicain
Idrossitetracaina [DCIT]
Oxitetracainum
4-Butylamino-2-hydroxy-benzoesaeure-(2-dimethylamino-aethylester)
Salicaine (anesthetic)
Hydroxytetracain
Hydroxamethocaine
Rhenocain
Hydroxytetracainum [INN-Latin]
4-butylamino-2-hydroxy-benzoic acid-(2-dimethylamino-ethyl ester)
Hydroxytetracaine

Chemical & Physical Properties

[ Density]:
1.114g/cm3

[ Boiling Point ]:
415.1ºC at 760mmHg

[ Molecular Formula ]:
C15H24N2O3

[ Molecular Weight ]:
280.36300

[ Flash Point ]:
204.9ºC

[ Exact Mass ]:
280.17900

[ PSA ]:
61.80000

[ LogP ]:
2.39560

[ Vapour Pressure ]:
1.76E-07mmHg at 25°C

[ Index of Refraction ]:
1.557

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VO1932000
CHEMICAL NAME :
Salicylic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester
CAS REGISTRY NUMBER :
490-98-2
BEILSTEIN REFERENCE NO. :
2125583
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C15-H24-N2-O3
MOLECULAR WEIGHT :
280.41
WISWESSER LINE NOTATION :
4MR DQ CVO2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intratracheal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 2,112,1952
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,40,1952

Synthetic Route

Precursor & DownStream

Precursor

  • Butyraldehyde
  • 4-Nitrosalicylic Acid
  • 2-Methoxy-4-nitrobenzonitrile
  • ethyl 2-hydroxy-4-nitrobenzoate
  • 4-aminosalicylic acid
  • 2-Chloroethyldimethylamine

DownStream


Related Compounds

  • 4-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]methyl}benzoic acid
  • (2R)-3-cyclohexyl-2-{[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopropyl]formamido}propanoic acid
  • 1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylbutanoyl]-4-methylpiperidine-4-carboxylic acid
  • 2-chloro-6-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]benzoic acid
  • 2-chloro-6-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]benzoic acid
  • 5-[7-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)heptanamido]-4-methylpentanoic acid
  • 4-[3-(dimethylamino)azetidin-1-yl]-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-oxobutanoic acid
  • 2-{N-cyclopropyl-1-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyridin-2-yl]formamido}acetic acid
  • 4-[(2S,3S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanamido]-3-methylbutanoic acid
  • tert-butyl N-{5-[(2R)-2-aminopropyl]-4-methyl-1,3-thiazol-2-yl}carbamate
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