4-Quinazolinone

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Names

[ CAS No. ]:
491-36-1

[ Name ]:
4-Quinazolinone

[Synonym ]:
MFCD00511302
Quinazolone,4
3,4-Dihydro-4-oxoquinazoline
QUINAZOLONE
T66 BVN EMJ
QUINAZOLIN-4-OL
4-oxo-3,4-dihydroquinazoline
T66 BVM ENJ
4-QUINAZOLINO
4(3H)-Quinazolinone
3,4-dihydroquinazolin-4-one
quinazolin-4(3H)-one
3H-quinazolinyl-4-one
quinazoline-4(3H)-one
4-QUINAZOLONE
4-Quinazolinol
T66 BN DNJ EQ
EINECS 207-735-8
4-Hydroxyquinazoline
Quinazolin-4-one
4(1H)-Quinazolinone
QUINAZOLINONE
4-HQN

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
324.8±15.0 °C at 760 mmHg

[ Melting Point ]:
216-219 °C(lit.)

[ Molecular Formula ]:
C8H6N2O

[ Molecular Weight ]:
146.146

[ Flash Point ]:
150.2±20.4 °C

[ Exact Mass ]:
146.048019

[ PSA ]:
45.75000

[ LogP ]:
0.30

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.705

[ Storage condition ]:
Desiccate at RT

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2300000
CHEMICAL NAME :
4(3H)-Quinazolinone
CAS REGISTRY NUMBER :
491-36-1
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H6-N2-O
MOLECULAR WEIGHT :
146.16
WISWESSER LINE NOTATION :
T66 BVM ENJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
609 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

Safety Information

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S36/37/39-S22

[ WGK Germany ]:
3

[ RTECS ]:
VA2300000

[ HS Code ]:
29335995

Precursor & DownStream

Precursor

  • Formaldehyde
  • Benzenecarboximidic acid, 2-amino- (9CI)
  • Methyl 2-aminobenzoate
  • Trimethyl orthoformate
  • Isatoic anhydride
  • Triethyl orthoformate
  • Formic Acid
  • aminobenzonitrile
  • Anthranilic acid
  • (Z)-Methanimidic acid

DownStream

  • 3-[3-(4-chlorophenyl)-3-oxoprop-1-en-2-yl]quinazolin-4-one
  • 2-(4-chlorophenyl)-3-(4-oxoquinazolin-3-yl)propanal
  • 2-(4-oxoquinazolin-3-yl)-N-phenylacetamide
  • 2,4-diphenyl-1H-pyrrol-3-amine
  • N-(3-nitrophenyl)-2-(4-oxoquinazolin-3-yl)acetamide
  • N-(3-methoxyphenyl)-2-(4-oxoquinazolin-3-yl)acetamide
  • N-(2-nitrophenyl)-2-(4-oxoquinazolin-3-yl)acetamide
  • 3-[3-(4-methoxyphenyl)-3-oxoprop-1-en-2-yl]quinazolin-4-one
  • N-(4-methoxyphenyl)-2-(4-oxoquinazolin-3-yl)acetamide
  • 3-[1-(4-chlorophenyl)-3-hydroxy-1-oxopropan-2-yl]quinazolin-4-one

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2-keto-4-quinazolinone
  • 6-Iodo-4-quinazolinone
  • 2-Amino-4-quinazolinone
  • 6-Bromo-4-quinazolinone
  • 3-Methyl-4-quinazolinone
  • 6-hydroxy-4-quinazolinone
  • methyl 4-[7-methyl-3,9-dioxo-2-(pyridin-3-ylmethyl)-4a,5,6,7,8,8a-hexahydro-1H-chromeno[2,3-c]pyrrol-1-yl]benzoate
  • 3-(3-(Chloromethyl)-1H-1,2,4-triazol-5-YL)pyridine
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-4-methylpentanoic acid
  • 3-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]sulfanyl-6-phenyl-1,2,4-triazinan-5-one
  • 1-(1-bromo-2-methylpropan-2-yl)-2,3-dihydro-1H-indene
  • Pentan-2-YL sulfamate
  • n-Boc-3,5-dibromo-DL-phenylalanine
  • 1-(3-Chloro-4-methoxyphenyl)ethane-1,2-diol
  • 4-(2-Furanyl)-2,2-dimethyl-1,3-dioxolane
  • Methyl decahydroquinoline-1-carboxylate
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