Luteolin

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Names

[ CAS No. ]:
491-70-3

[ Name ]:
Luteolin

[Synonym ]:
EINECS 207-741-0
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
Flavopurpol
5,7,3',4'-tetrahydroxyflavon
3' 4' 5 7-tetrahydroxyflavone
LUTEOLOL
3',4',5,7-tetrahydroxy-flavone
FLACITRAN
Cyanidenon 1470
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
Digitoflavone
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone
5,7,3',4'-tetrahydroxyflavone
Daphneflavonol
weldlake
cyanidenon
Luteolin
3',4',5,7-Tetrahydroxyflavone
Salifazide
MFCD08460272

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
616.1±55.0 °C at 760 mmHg

[ Melting Point ]:
~330 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₀O₆

[ Molecular Weight ]:
286.236

[ Flash Point ]:
239.5±25.0 °C

[ Exact Mass ]:
286.047729

[ PSA ]:
111.13000

[ LogP ]:
2.40

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.768

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK9275210

CHEMICAL NAME :: Flavone, 3',4',5,7-tetrahydroxy-

CAS REGISTRY NUMBER :: 491-70-3

BEILSTEIN REFERENCE NO. :: 0292084

LAST UPDATED :: 199806

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H10-O6

MOLECULAR WEIGHT :: 286.25

WISWESSER LINE NOTATION :: T66 BO EVT&J CR CQ DQ& GQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 20 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LK9275210

[ HS Code ]:
2932999099

Precursor & DownStream

Precursor

5,7,3',4'-Tetramethoxyflavone
Apigenin
Isoquercitrin
2-(3,4-bis(benzyloxy)phenyl)-5,7-dihydroxy-4H-chromen-4-one
Luteolin-7-O-glucoside
3,4-dibenzyloxybenzaldehyde
1-[2-hydroxy-4,6-bis(methoxymethoxy)phenyl]ethanone

DownStream

[2-acetyloxy-4-(5,7-diacetyloxy-4-oxochromen-2-yl)phenyl] acetate
Hydroxygenkwanin
protocatechuic acid
Phloroglucinol
Diosmetin
Chrysoeriol
Velutin
Pilloin
5,7,3',4'-Tetramethoxyflavone
5-Hydroxy-3',4',7-trimethoxyflavone

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling.

PLoS ONE 10 , e0137106, (2015)

Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will ...

Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.

Bioorg. Med. Chem. 23 , 4746-54, (2015)

The ability of TRAIL to selectively induce apoptosis in cancer cells while sparing normal cells makes it an attractive target for the development of new cancer therapy. In search of bioactive natural ...

Metabolite profiling of polyphenols in the Tunisian plant Tamarix aphylla (L.) Karst.

J. Pharm. Biomed. Anal. 99 , 97-105, (2014)

In this study, a detailed investigation on the composition of polyphenols of Tamarix aphylla (L.) Karst., consisting of phenolic acids and flavonoids, was carried out. In order to optimize the yield o...