N,N-BIS(2-CHLOROETHYL)-2-NAPHTHYLAMINE

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Names

[ CAS No. ]:
494-03-1

[ Name ]:
N,N-BIS(2-CHLOROETHYL)-2-NAPHTHYLAMINE

[Synonym ]:
Nafticlorina
Chlornaftina
Chloronaftina
Chlornaphthin
Aleukon
Chlornaphazine
Chloronaphthina
Cloronaftina
Chloronaphthine
Chlornaphazin

Chemical & Physical Properties

[ Density]:
1.234g/cm3

[ Boiling Point ]:
414.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₅Cl₂N

[ Molecular Weight ]:
268.18200

[ Flash Point ]:
204.4ºC

[ Exact Mass ]:
267.05800

[ PSA ]:
3.24000

[ LogP ]:
4.12380

[ Vapour Pressure ]:
4.49E-07mmHg at 25°C

[ Index of Refraction ]:
1.63

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QM2450000

CHEMICAL NAME :: 2-Naphthylamine, N,N-bis(2-chloroethyl)-

CAS REGISTRY NUMBER :: 494-03-1

BEILSTEIN REFERENCE NO. :: 3316600

LAST UPDATED :: 199612

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C14-H15-Cl2-N

MOLECULAR WEIGHT :: 268.20

WISWESSER LINE NOTATION :: L66J CN2G2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1086 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 2468 mg/kg/6Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 3132 mg/kg/10Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 3200 mg/kg/11Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg/4W

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 4090 mg/kg/7Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 3200 mg/kg/11Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 120 ug/L

REFERENCE :: AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980- Volume(issue)/page/year: 1,241,1980 *** REVIEWS *** IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,119,1974 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,119,1974 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,130,1987 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970

Precursor & DownStream

Precursor

DownStream

Related Compounds

N,N-bis(2-chloroethyl)-2-phenylethanamine,hydrochloride
N,N-bis(2-chloroethyl)-2-methoxyphenothiazine-10-carboxamide
N,N-bis(2-chloroethyl)-2-phenoxyacetamide
N,N-bis(2-chloroethyl)-2-sulfanylidene-1-oxa-3-thia-2$l^C7H14Cl2NOPS2-phosphacyclohexan-2-amine
N,N-bis(2-chloroethyl)-2-ethoxyethanamine,hydrochloride
N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-dithiaphospholan-2-amine
5-(3-Amino-3-methylbutyl)-2-nitrophenol
5-(2-Methylpyridin-4-yl)-1,2-oxazole-3-carboxylic acid
2-[1-(2-Fluoro-3-nitrophenyl)cyclopropyl]acetic acid
tert-butyl N-[1-(4-nitro-1H-pyrazol-3-yl)-2-oxoethyl]carbamate
2-tert-butyl-5-(1-isocyanatoethyl)-2H-1,2,3,4-tetrazole
3-(3-Tert-butylphenyl)-2,2-dimethylpropan-1-ol
3-Amino-3-(4-fluoro-3-methylphenyl)cyclobutan-1-ol
tert-butyl N-{1-[1-(aminomethyl)-4-hydroxycyclohexyl]cyclopentyl}carbamate
3-(5-Bromo-2-fluoropyridin-3-yl)propane-1-thiol
3-Bromo-5-methyl-2-(2-nitroethenyl)thiophene

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