6β-Naltrexol

[ Density]:
1.48g/cm3

[ Boiling Point ]:
557.5ºC at 760mmHg

[ Melting Point ]:
90-96ºC

[ Molecular Formula ]:
C₂₀H₂₅NO₄

[ Molecular Weight ]:
343.42

[ Flash Point ]:
291ºC

[ Exact Mass ]:
343.17800

[ PSA ]:
73.16000

[ LogP ]:
1.25510

[ Index of Refraction ]:
1.719

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Conformational analysis of 6α- and 6β-naltrexol and derivatives and relationship to opioid receptor affinity.

J. Chem. Inf. Model. 52(2) , 391-5, (2012)

Naltrexol and its C₆ α and β desoxy, iodo, mesyl, tosyl, trifyl, dimethylcarbamyl, and diphenylcarbamyl derivatives were studied in their energy-minimized C ring chair-like and boat-like conformations...

In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs.

Eur. J. Pharm. Sci. 33(4-5) , 371-9, (2008)

6-Beta-naltrexol is the major active metabolite of naltrexone, NTX, a potent mu-opioid receptor antagonist used in the treatment of alcohol dependence and opioid abuse. Compared to naloxone, NTX has a...

Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys.

Psychopharmacology 195(4) , 479-86, (2008)

Some opioid receptor ligands that appear to be neutral antagonists can have inverse agonist activity under conditions of increased constitutive activity (e.g., agonist treatment).This study compared t...

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