oxazolidinone

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Names

[ CAS No. ]:
497-25-6

[ Name ]:
oxazolidinone

[Synonym ]:
2-Oxazolidinone
oxazolidinone
oxazolidin-2-one
2-oxazolidone
trans-oxazolidinone
EINECS 207-840-9
MFCD00005268
1,3-Oxazolidin-2-one

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
171.0±23.0 °C at 760 mmHg

[ Melting Point ]:
86-89ºC

[ Molecular Formula ]:
C₃H₅NO₂

[ Molecular Weight ]:
87.077

[ Flash Point ]:
57.2±22.6 °C

[ Exact Mass ]:
87.032028

[ PSA ]:
38.33000

[ LogP ]:
-0.99

[ Vapour Pressure ]:
0.5±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.548

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ2450000

CHEMICAL NAME :: 2-Oxazolidinone

CAS REGISTRY NUMBER :: 497-25-6

BEILSTEIN REFERENCE NO. :: 0106251

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C3-H5-N-O2

MOLECULAR WEIGHT :: 87.09

WISWESSER LINE NOTATION :: T5MVOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 2,168,1959

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 2,168,1959

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36;R43

[ Safety Phrases ]:
S26-S36/37

[ WGK Germany ]:
3

[ RTECS ]:
RQ2450000

[ HS Code ]:
29322980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

carbon monoxide
2-Aminoethanol
Ethylene carbonate
1-ethyleneimine
(2-amino-5-methylphenyl)-(2-bromophenyl)methanone
benzyloxyamine
1,1-dimethylethyl [(1S)-2-oxo-2-(2-oxo-3-oxazolidinyl)-1-(phenylmethyl)ethyl]carbamate
methyl 2-(2-methoxycarbonylphenoxy)carbonyloxybenzoate
Urea
Ethyl carbonate

DownStream

3-(3-phenylprop-2-enoyl)-1,3-oxazolidin-2-one
N-Trimethylsilyl-2-oxazolidinone
N'-(3-bromophenyl)ethane-1,2-diamine
2-Oxazolidinone, 3-(bromoacetyl)- (9CI)
3, 4-Dihydrobenzo[f][1, 4]thiazepin-5(2H)-one
Ethanolamine-O-sulfate
3-(2-bromopentanoyl)-1,3-oxazolidin-2-one
2-Pyrrolidinone
2-Phenylethanamine
Bibenzyl

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%