DESACETYLCOLCHICINE-d-TARTRATE

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Names

[ Name ]:
DESACETYLCOLCHICINE-d-TARTRATE

[Synonym ]:
Colchicine,deacetyl-,L-tartrate
NCI 1136
TMCA methyl ester d-tartrate,hydrate
SKF 250
Trimethylcolchicinic acid,methyl ether,L-tartrate
Desacetylcolchicine d-tartrate

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₉NO₁₁

[ Molecular Weight ]:
507.48700

[ Exact Mass ]:
507.17400

[ PSA ]:
195.07000

[ LogP ]:
1.27190

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0980000

CHEMICAL NAME :: Colchicinic acid, trimethyl-methyl ether, d-tartrate, hydrate

CAS REGISTRY NUMBER :: 49720-72-1

LAST UPDATED :: 199610

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H23-N-O5.C4-H6-O6.H2-O

MOLECULAR WEIGHT :: 525.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 200 ug/kg/7D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia

REFERENCE :: CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,263,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70520 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 9500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

Related Compounds

(-)-DIBUTYL-D-TARTRATE
ferrous-d-tartrate
ROSIGLITAZONE D-TARTRATE
dibutyl D-tartrate
Isofagomine D-Tartrate
(-)-Dimethyl d-Tartrate
3-Methyl-3-{[5-(trifluoromethyl)furan-2-yl]oxy}azetidine
O-[1-(2-ethylphenyl)ethyl]hydroxylamine
1-[(3-phenyl-1H-pyrazol-4-yl)methyl]cyclopropane-1-carboxylic acid
2,2-Dimethyl-1-(1,2,2,2-tetrafluoroethyl)cyclopropan-1-amine
(1R)-3-amino-1-(2-methoxy-6-methylphenyl)propan-1-ol
4-Chloronaphthalene-2-sulfonamide
tert-butyl N-(1-amino-4-cyclopentylbutan-2-yl)carbamate
5-(4-Methoxy-2-nitrophenyl)-1,3-oxazolidin-2-one
3-(3-Bromo-2-methoxyphenyl)propane-1-thiol
3-[2-(aminomethyl)prop-2-en-1-yl]-1H-indole

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