DESACETYLCOLCHICINE-d-TARTRATE

Suppliers

Names

[ Name ]:
DESACETYLCOLCHICINE-d-TARTRATE

[Synonym ]:
Colchicine,deacetyl-,L-tartrate
NCI 1136
TMCA methyl ester d-tartrate,hydrate
SKF 250
Trimethylcolchicinic acid,methyl ether,L-tartrate
Desacetylcolchicine d-tartrate

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₉NO₁₁

[ Molecular Weight ]:
507.48700

[ Exact Mass ]:
507.17400

[ PSA ]:
195.07000

[ LogP ]:
1.27190

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0980000

CHEMICAL NAME :: Colchicinic acid, trimethyl-methyl ether, d-tartrate, hydrate

CAS REGISTRY NUMBER :: 49720-72-1

LAST UPDATED :: 199610

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H23-N-O5.C4-H6-O6.H2-O

MOLECULAR WEIGHT :: 525.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 200 ug/kg/7D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia

REFERENCE :: CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,263,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70520 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 9500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

Related Compounds

(-)-DIBUTYL-D-TARTRATE
ferrous-d-tartrate
ROSIGLITAZONE D-TARTRATE
dibutyl D-tartrate
Isofagomine D-Tartrate
(-)-Dimethyl d-Tartrate
2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)propanamide
Ethyl 1-((2-benzamidoethyl)sulfonyl)piperidine-3-carboxylate
N-{2-[(3,5-dimethylpiperidin-1-yl)sulfonyl]ethyl}benzamide
N-(2-(N-((tetrahydrofuran-2-yl)methyl)sulfamoyl)ethyl)benzamide
3-methoxy-N-(2-((3-methylpiperidin-1-yl)sulfonyl)ethyl)benzamide
Ethyl 1-((2-(3-methoxybenzamido)ethyl)sulfonyl)piperidine-3-carboxylate
N-(2-((3,5-dimethylpiperidin-1-yl)sulfonyl)ethyl)-3-methoxybenzamide
3-methoxy-N-(2-((4-(4-methoxyphenyl)piperazin-1-yl)sulfonyl)ethyl)benzamide
3-methoxy-N-[2-(4-phenylbutan-2-ylsulfamoyl)ethyl]benzamide
3-methoxy-N-(2-(N-pentylsulfamoyl)ethyl)benzamide

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.