NORBORNENE

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Names

[ CAS No. ]:
498-66-8

[ Name ]:
NORBORNENE

[Synonym ]:
2-Norbornene
norcamphene
norborn-2-ene
Norbornylene,stabilized
EINECS 207-866-0
Bicyclo[2.2.1]hept-2-ene
bicyclo[2.2.1]hept-5-ene
norbornylene
MFCD00082304
2-norbornylene
bicyclo(2,2,1)hept-2Z-ene
bicyclo(2.2.1)heptene
Norbornene
3,6-Endomethylenecyclohexene
Norfenchene

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
96.0±0.0 °C at 760 mmHg

[ Melting Point ]:
44-46 °C(lit.)

[ Molecular Formula ]:
C₇H₁₀

[ Molecular Weight ]:
94.154

[ Flash Point ]:
-15.0±0.0 °C

[ Exact Mass ]:
94.078247

[ LogP ]:
2.75

[ Vapour Pressure ]:
50.7±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.520

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RB7900000

CHEMICAL NAME :: 2-Norbornene

CAS REGISTRY NUMBER :: 498-66-8

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H10

MOLECULAR WEIGHT :: 94.17

WISWESSER LINE NOTATION :: L55 A CUTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 3 mg/m3 JAN 1993

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H228-H319-H411

[ Precautionary Statements ]:
P210-P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
F:Highlyflammable;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S9-S16-S29-S33

[ RIDADR ]:
UN 1325 4.1/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
RB7900000

[ Packaging Group ]:
II

[ Hazard Class ]:
4.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

5-(phenylsulfonyl)bicyclo[2.2.1]hept-2-ene
Norbornadiene
ethene
Tricyclo[5.2.1.02,6]deca-3,8-diene
exo-2-norbornyl iodide
EXO-2-BROMONORBORNANE
3-iodobicyclo[2.2.1]heptane
Cyclopentadiene
endo-3-(trimethylsilyl)-endo-2-norbornyl mesylate

DownStream

diexo-3-Amino-bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester
Bicyclo[2.2.1]heptane-2-carboxamide, 3-amino-, (1R,2S,3R,4S)-rel- (9CI)
Bromocyclobutane
syn-2-chloro-7-hydroxynorbornane
3-Chlorobicyclo[3.2.1]oct-2-ene
Perchlorothiophene
1,1,2,2-Ethenetetracarboxylicacid, 1,1,2,2-tetramethyl ester
(1S,4S,4aR,8aS)-5,6,7,8-tetrachloro-1,2,3,4,4a,8a-hexahydro-1,4-methanonaphthalene
3-oxatricyclo[3.2.1.02,4]octane
4-(Methylamino)benzonitrile

Articles

Self-activation in de novo designed mimics of cell-penetrating peptides.

Angew. Chem. Int. Ed. Engl. 50 , 6147, (2011)

[Establishment of the maximum permissible concentrations of norbornene, norbornadiene and dicyclopentadiene in reservoir water].

Gig. Sanit. (2) , 77-9, (1986)

Pd(II)-catalyzed regioselective 2-alkylation of indoles via a norbornene-mediated C-H activation: mechanism and applications.

J. Am. Chem. Soc. 134(35) , 14563-72, (2012)

A palladium-catalyzed direct 2-alkylation reaction of free N-H indoles was developed based on a norbornene-mediated regioselective cascade C-H activation. The detailed reaction mechanism was investiga...