proxymetacaine

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Names

[ CAS No. ]:
499-67-2

[ Name ]:
proxymetacaine

[Synonym ]:
2-(diethylamino)ethyl 3-amino-4-propoxybenzoate

Chemical & Physical Properties

[ Density]:
1.065 g/cm3

[ Boiling Point ]:
434.4ºC at 760 mmHg

[ Melting Point ]:
182-183.30C

[ Molecular Formula ]:
C16H26N2O3

[ Molecular Weight ]:
294.38900

[ Flash Point ]:
216.5ºC

[ Exact Mass ]:
294.19400

[ PSA ]:
64.79000

[ LogP ]:
3.13740

[ Vapour Pressure ]:
9.5E-08mmHg at 25°C

[ Index of Refraction ]:
1.527

[ Storage condition ]:
Refrigerator

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG3058000
CHEMICAL NAME :
Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester
CAS REGISTRY NUMBER :
499-67-2
BEILSTEIN REFERENCE NO. :
2745891
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C16-H26-N2-O3
MOLECULAR WEIGHT :
294.44
WISWESSER LINE NOTATION :
3OR BZ DVO2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4800 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 63,369,1938 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0782 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 14 (estimated)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-NITRO-4-PROPOXY-, 2-(DIETHYLAMINO)ETHYL ESTER BENZOIC ACID
  • 4-Hydroxy-3-nitrobenzoic acid
  • 4-Propoxy-3-nitrobenzoic acid

DownStream

Related Compounds

  • Proxymetacaine Hcl
  • [2-(1,4-dimethyl-1H-pyrazol-5-yl)propan-2-yl](methyl)amine
  • [2-(1,3-dimethyl-1H-pyrazol-5-yl)propan-2-yl](methyl)amine
  • 4-Bromo-2-(2-fluoropropan-2-yl)-1,3-thiazole
  • [2-(1,3-dimethyl-1H-pyrazol-4-yl)propan-2-yl](methyl)amine
  • [2-(1,5-dimethyl-1H-pyrazol-4-yl)propan-2-yl](methyl)amine
  • 1-[1-Methyl-3-(propan-2-yl)-1H-pyrazol-5-yl]ethan-1-amine
  • 1-(1,5-dimethyl-1H-pyrazol-4-yl)-2-methylpropan-2-amine
  • 1-(1,3-dimethyl-1H-pyrazol-4-yl)-2-methylpropan-2-amine
  • 3-(1,4-dimethyl-1H-pyrazol-5-yl)butan-1-amine
  • 1-(1,4-dimethyl-1H-pyrazol-5-yl)-2-methylpropan-2-amine
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