Guanidine hydrochloride

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Names

[ CAS No. ]:
50-01-1

[ Name ]:
Guanidine hydrochloride

[Synonym ]:
ZYZUM &&HCl
Guanidine hydrochloride (1:1)
guanidinium chloride
Guanidine, hydrochloride (1:1)
Guanidine monohydrochloride
Amino(imino)methanaminium chloride
GdmCl
Guanidine (hydrochloride)
guanidine chlorhydrate
hydrochloric acid guanidine
Aminoformamidine hydrochloride,Aminomethanamidine hydrochloride,Guanidinium chloride
Guanidine Hydrochlor
Guanidine chloride
Aminoformamidine hydrochloride
GUANIDIUM CHLORIDE
GUHY
Aminoformamidine hydrochloride,Guanidinium chloride,Guanidium chloride
1-methylguanidine hydrochloride
Aminomethanamidine hydrochlorid
MFCD00013026
AMINOFORMAMIDINE HCL
Guanidinehydrochloride
Guanidine, monohydrochloride
usafek-749
EINECS 200-002-3
Guanidinhydrochlorid
Guanidine Hydrochloride
Guanidine HCl
guanidinium hydrochloride

Chemical & Physical Properties

[ Density]:
1.18 g/mL at 25 °C(lit.)

[ Boiling Point ]:
132.9ºC at 760 mmHg

[ Melting Point ]:
180-185 °C(lit.)

[ Molecular Formula ]:
CH₆ClN₃

[ Molecular Weight ]:
95.531

[ Exact Mass ]:
95.025024

[ PSA ]:
75.89000

[ LogP ]:
1.14090

[ Index of Refraction ]:
n20/D 1.465

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Hygroscopic. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
2280 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF4300000

CHEMICAL NAME :: Guanidine, monohydrochloride

CAS REGISTRY NUMBER :: 50-01-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C-H5-N3.Cl-H

MOLECULAR WEIGHT :: 95.55

WISWESSER LINE NOTATION :: ZYZUM &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 475 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 404 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 571 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Behavioral - irritability

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraarterial

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 4 mmol/L

REFERENCE :: BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 53,531,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3755 No. of Facilities: 115 (estimated) No. of Industries: 2 No. of Occupations: 22 No. of Employees: 2097 (estimated) No. of Female Employees: 589 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H332-H315-H319

[ Precautionary Statements ]:
P261-P280-P301 + P312 + P330-P304 + P340 + P312-P305 + P351 + P338-P337 + P313

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/38

[ Safety Phrases ]:
S26-S36-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
MF4300000

[ HS Code ]:
2925290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Urea
Carbon tetrachloride
Ammonia
Aluminium chloride
molecular iodine
Ethyl carbamimidate hydrochloride
1-Methylbiguanide monohydrochloride

DownStream

4-(6-phenylpyridin-3-yl)pyrimidin-2-amine
Methyl 2-Aminopyrimidine-5-carboxylate
2-Amino-5,6,7,8-tetrahydro-3H-quinazolin-4-one
5-Methylpyrimidin-2-amine
2-Amino-6-hydroxy-4-methylpyrimidine
amidinourea
9-Benzyladenine
8-fluoro-1-oxido-1,2,4-benzotriazin-1-ium-3-amine
2,4-Quinazolinediamine,6-methyl-
4,6-bis(4-chlorophenyl)pyrimidin-2-amine

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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