Mitomycin C

Names

[ CAS No. ]:
50-07-7

[ Name ]:
Mitomycin C

[Synonym ]:
MFCD00078109
Mitomycin C(Ametycine)
EINECS 200-008-6

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
532.0±60.0 °C at 760 mmHg

[ Melting Point ]:
360 °C

[ Molecular Formula ]:
C₁₅H₁₈N₄O₅

[ Molecular Weight ]:
334.327

[ Flash Point ]:
275.5±32.9 °C

[ Exact Mass ]:
334.127716

[ PSA ]:
146.89000

[ LogP ]:
-0.27

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.828

[ Stability ]:
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.

[ Water Solubility ]:
soluble

MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H351

[ Precautionary Statements ]:
P201-P202-P280-P301 + P310 + P330-P308 + P313-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R40

[ Safety Phrases ]:
S36/37-S45-S28A-S28

[ RIDADR ]:
UN 3462 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
CN0700000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

albomitomycin A
1a-acetyl-7-demethoxy-6,7-dihydro-7,7-(ethylenedioxy)-6-(phenylselenyl)mitomycin A
Isomitomycin A
(8aS)-8a-bromoalbomitomycin A
diphenylmethylamine
N(6)-((dimethylamino)methylene)mitomycin C

DownStream

Mitomycin A
Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-(methylamino)-,[1aS-(1aa,8b,8aa,8ba)]- (9CI)
Porfiromycin
10-O-Decarbamoyl-10-O-methanesulfonylmitomycin C
Azirino[2',3'_3,4]pyrrolo[1,2-.α.]indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6-hydroxy-8-(hydroxymethyl)-8a-methoxy-5-methyl-, 8-carbamate

Articles

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.

J. Cell Biol. 206(2) , 183-97, (2014)

Deoxyribonucleic acid (DNA) lesions encountered during replication are often bypassed using DNA damage tolerance (DDT) pathways to avoid prolonged fork stalling and allow for completion of DNA replica...

Sodium fluoride promotes apoptosis by generation of reactive oxygen species in human lymphocytes.

J. Toxicol. Environ. Health A 77(21) , 1269-80, (2014)

Fluoride generated the attention of toxicologists due to its deleterious effects at high concentrations in human populations suffering from fluorosis and with in vivo experimental models. Interest in ...

Piperine inhibits the growth and motility of triple-negative breast cancer cells.

Cancer Lett. 357(1) , 129-40, (2014)

Piperine, an alkaloid from black pepper, is reported to have anticancer activities. In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (T...

Mitomycin C
mitomycin C
Mitomycin C
leucomitomycin C
MITOMYCIN C DERIV
MITOMYCIN C ANALOG
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
4-(N,N-bis(2-methoxyethyl)sulfamoyl)-N-(4-ethylbenzo[d]thiazol-2-yl)benzamide
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
4-methoxy-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)benzene-1-sulfonamide
(4-Methyl-tetrahydro-furan-2-yl)-methanol
1-(2-(Benzo[d][1,3]dioxol-5-yl)-9-chloro-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde