Cyclophosphamide

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Names

[ CAS No. ]:
50-18-0

[ Name ]:
Cyclophosphamide

[Synonym ]:
ASTA
N,N-Bis(b-chloroethyl)-N',O-propylenephosphoric Acid Ester Diamide
cycloblastin
cyclophosphane
2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide
N,N-bis(2-chloroéthyl)-1,3,2-oxazaphosphinan-2-amine-2-oxyde
2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide
Mitoxan
cytophosphan
B 518
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
EINECS 200-015-4
N,N-Bis(b-chloroethyl)-N',O-trimethylenephosphoric Acid Ester Diamide
CB 4564
2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
Clafen
Cytoxan
Endoxana
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
Endoxan
UNII:6UXW23996M
Enduxan
2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
Neosar
Genoxal
Cyclophosphamide
2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazophosphorine 2-Oxide
2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide (9CI)
(RS)-Cyclophosphamide
Ciclophosphamide
(±)-Cyclophosphamide
2-(bis(2-Chloroethyl)-amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
336.1±52.0 °C at 760 mmHg

[ Melting Point ]:
41-45ºC

[ Molecular Formula ]:
C₇H₁₅Cl₂N₂O₂P

[ Molecular Weight ]:
261.086

[ Flash Point ]:
157.1±30.7 °C

[ Exact Mass ]:
260.024811

[ PSA ]:
51.38000

[ LogP ]:
0.23

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.506

[ Stability ]:
Stable, but light sensitive. Incompatible with oxidizing agents.

[ Water Solubility ]:
Soluble. 1-5 g/100 mL at 23 ºC

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
UN 1851

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

dechloroethylcyclophosphamide
4-Hydroperoxy cyclophosphamide
Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide
2H-1,3,2-Oxazaphosphorin-2-amine,4,4'-dioxybis[N,N-bis(2-chloroethyl)tetrahydro-, 2,2'-dioxide
4H-1,3,2-Oxazaphosphorin-4-one,2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide
Propanoic acid,3-[[amino[bis(2-chloroethyl)amino]phosphinyl]oxy]-
aldophosphamide
Chloroacetaldehyde
acrolein
1H,5H-[1,3,2]Diazaphospholo[2,1-b][1,3,2]oxazaphosphorine,1-(2-chloroethyl)tetrahydro-, 9-oxide

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%